Molecule Details
InChIKeyUWQBVYXTLXNIOO-UHFFFAOYSA-N
Compound Name1-Pyrazin-2-yl-3-[7-(trifluoromethyl)quinolin-4-yl]urea
Canonical SMILESO=C(Nc1cnccn1)Nc1ccnc2cc(C(F)(F)F)ccc12
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)10
Pfam Stratification Cross-Family
Avg pChEMBL6.54
SourceChEMBL
2D Structure
2D structure
Activity Profile
Target Activities (10)
Target Gene Organism Category Pfam pChEMBL Type Source
P49840 GSK3A Homo sapiens Human PF00069 7.6 Ki ChEMBL
Q9HAZ1 CLK4 Homo sapiens Human PF00069 7.4 Ki ChEMBL
P49841 GSK3B Homo sapiens Human PF00069 7.2 Ki ChEMBL
Q9UEE5 STK17A Homo sapiens Human PF00069 6.7 Ki ChEMBL
P35916 FLT4 Homo sapiens Human PF07679 PF13927 PF22971 PF07714 PF21339 PF17988 PF22854 6.2 Ki ChEMBL
P49760 CLK2 Homo sapiens Human PF00069 6.2 Ki ChEMBL
Q13627 DYRK1A Homo sapiens Human PF00069 6.1 Ki ChEMBL
O96017 CHEK2 Homo sapiens Human PF00498 PF00069 6.0 Ki ChEMBL
P35968 KDR Homo sapiens Human PF07679 PF00047 PF13895 PF22971 PF07714 PF21339 PF17988 PF22854 6.0 Ki ChEMBL
Q9HBY8 SGK2 Homo sapiens Human PF00069 PF00433 6.0 Ki ChEMBL