Molecule Details
| InChIKey | UVKZSORBKUEBAZ-UHFFFAOYSA-N |
|---|---|
| Compound Name | Cyclizine |
| Canonical SMILES | CN1CCN(C(c2ccccc2)c2ccccc2)CC1 |
| Clinical Status | Clinical Multi-Target |
| Targets (Human+Pathogen) | 13 |
| Pfam Stratification | Cross-Family |
| Avg pChEMBL | 6.5 |
| Source | ChEMBL;TTD_MultiTarget |
2D Structure
Activity Profile
DrugBank Annotations
| DrugBank ID | DB01176 |
|---|---|
| Drug Name | Cyclizine |
| CAS Number | 82-92-8 |
| Groups | approved withdrawn |
| ATC Codes | R06AE03 R06AE53 |
| Description | A histamine H1 antagonist given by mouth or parenterally for the control of postoperative and drug-induced vomiting and in motion sickness. (From Martindale, The Extra Pharmacopoeia, 30th ed, p935) |
Categories: Antiemetics Antihistamines for Systemic Use Autonomic Agents Central Nervous System Agents Central Nervous System Depressants Cytochrome P-450 CYP2C9 Inhibitors Cytochrome P-450 CYP2C9 Inhibitors (strength unknown) Cytochrome P-450 Enzyme Inhibitors Gastrointestinal Agents Histamine Agents Histamine Antagonists Histamine H1 Antagonists Neurotransmitter Agents Peripheral Nervous System Agents Piperazine Derivatives Piperazines Potential QTc-Prolonging Agents QTc Prolonging Agents
Cross-references: ChEBI: 3994 CHEMBL648 ChemSpider: 6470 Drugs Product Database (DPD): 9111 C06930 D03621 PharmGKB: PA164742937 PubChem:6726 PubChem:46506232 RxCUI: 2977 Therapeutic Targets Database: DAP000337 Wikipedia: Cyclizine ZINC: ZINC000019156872
Target Activities (13)
| Target | Gene | Organism | Category | Pfam | pChEMBL | Type | Source |
|---|---|---|---|---|---|---|---|
| P35367 | HRH1 | Homo sapiens | Human | PF00001 | 7.9 | IC50 | ChEMBL |
| P28223 | HTR2A | Homo sapiens | Human | PF00001 | 6.9 | IC50 | ChEMBL |
| P41595 | HTR2B | Homo sapiens | Human | PF00001 | 6.5 | IC50 | ChEMBL |
| P08173 | CHRM4 | Homo sapiens | Human | PF00001 | 6.5 | IC50 | ChEMBL |
| P11229 | CHRM1 | Homo sapiens | Human | PF00001 | 6.5 | IC50 | ChEMBL |
| P20309 | CHRM3 | Homo sapiens | Human | PF00001 | 6.5 | IC50 | ChEMBL |
| P08172 | CHRM2 | Homo sapiens | Human | PF00001 | 6.4 | Ki | ChEMBL |
| P08912 | CHRM5 | Homo sapiens | Human | PF00001 | 6.3 | IC50 | ChEMBL |
| P28335 | HTR2C | Homo sapiens | Human | PF00001 | 6.3 | Ki | ChEMBL |
| P08913 | ADRA2A | Homo sapiens | Human | PF00001 | 6.2 | Ki | ChEMBL |
| P25100 | ADRA1D | Homo sapiens | Human | PF00001 | 6.2 | Ki | ChEMBL |
| P35348 | ADRA1A | Homo sapiens | Human | PF00001 | 6.2 | pIC50 | TTD_MultiTarget |
| Q01959 | SLC6A3 | Homo sapiens | Human | PF00209 | 6.2 | IC50 | ChEMBL |