Molecule Details
InChIKeyUVHNIMCYDWMRAE-LOTSEXGMSA-N
Compound Name1-[(2S,3S)-3-[[5-fluoro-2-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl]amino]-2-bicyclo[2.2.2]octanyl]ethanol
Canonical SMILESCC(O)[C@H]1C2CCC(CC2)[C@@H]1Nc1nc(-c2c[nH]c3ncc(F)cc23)ncc1F
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)9
Pfam Stratification Cross-Family
Avg pChEMBL6.55
SourceChEMBL
2D Structure
2D structure
Activity Profile
Target Activities (9)
Target Gene Organism Category Pfam pChEMBL Type Source
P49840 GSK3A Homo sapiens Human PF00069 7.2 Ki ChEMBL
P49841 GSK3B Homo sapiens Human PF00069 7.2 Ki ChEMBL
P36888 FLT3 Homo sapiens Human PF00047 PF07714 6.8 Ki ChEMBL
O60674 JAK2 Homo sapiens Human PF18379 PF18377 PF17887 PF07714 PF21990 6.6 Ki ChEMBL
O75116 ROCK2 Homo sapiens Human PF25346 PF00069 PF08912 6.5 Ki ChEMBL
Q13464 ROCK1 Homo sapiens Human PF25346 PF00069 PF08912 6.5 Ki ChEMBL
P48736 PIK3CG Homo sapiens Human PF00454 PF00792 PF00794 PF00613 PF19710 6.1 Ki ChEMBL
P12931 SRC Homo sapiens Human PF07714 PF00017 PF00018 6.0 Ki ChEMBL
P53350 PLK1 Homo sapiens Human PF00069 PF00659 6.0 Ki ChEMBL