Molecule Details
InChIKeyUVEBMCRIHHZDFG-UHFFFAOYSA-N
Compound NameN-cyclopentyl-5-[2-[[5-(4-ethylpiperazin-1-yl)-2-pyridinyl]amino]-5-fluoropyrimidin-4-yl]-4-methyl-1,3-thiazol-2-amine
Canonical SMILESCCN1CCN(c2ccc(Nc3ncc(F)c(-c4sc(NC5CCCC5)nc4C)n3)nc2)CC1
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)8
Pfam Stratification Cross-Family
Avg pChEMBL7.38
SourceChEMBL;BindingDB
2D Structure
2D structure
Activity Profile
Target Activities (8)
Target Gene Organism Category Pfam pChEMBL Type Source
P11802 CDK4 Homo sapiens Human PF00069 8.7 Ki ChEMBL;BindingDB
P24385 CCND1 Homo sapiens Human PF02984 PF00134 8.7 Ki ChEMBL
P30281 CCND3 Homo sapiens Human PF02984 PF00134 8.2 Ki ChEMBL
Q00534 CDK6 Homo sapiens Human PF00069 8.2 Ki ChEMBL;BindingDB
P20248 CCNA2 Homo sapiens Human PF02984 PF00134 PF16500 6.5 Ki ChEMBL
P24941 CDK2 Homo sapiens Human PF00069 6.5 Ki ChEMBL;BindingDB
P50613 CDK7 Homo sapiens Human PF00069 6.2 Ki ChEMBL
P51946 CCNH Homo sapiens Human PF16899 PF00134 6.2 Ki ChEMBL;BindingDB