Molecule Details
InChIKeyUUWNXFJBBYAMDT-UHFFFAOYSA-N
Compound Name2,6-difluoro-N-(3-phenyl-1H-pyrrolo[2,3-b]pyridin-5-yl)benzamide
Canonical SMILESO=C(Nc1cnc2[nH]cc(-c3ccccc3)c2c1)c1c(F)cccc1F
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)46
Pfam Stratification Cross-Family
Avg pChEMBL6.61
SourceChEMBL
2D Structure
2D structure
Activity Profile
Target Activities (46)
Target Gene Organism Category Pfam pChEMBL Type Source
P06241 FYN Homo sapiens Human PF07714 PF00017 PF00018 8.5 Ki ChEMBL
P42685 FRK Homo sapiens Human PF07714 PF00017 PF00018 8.5 Ki ChEMBL
P00519 ABL1 Homo sapiens Human PF08919 PF07714 PF00017 PF00018 8.0 Ki ChEMBL
P06239 LCK Homo sapiens Human PF07714 PF00017 PF00018 7.9 Ki ChEMBL
P12931 SRC Homo sapiens Human PF07714 PF00017 PF00018 7.8 Ki ChEMBL
P07948 LYN Homo sapiens Human PF07714 PF00017 PF00018 7.5 Ki ChEMBL
Q16288 NTRK3 Homo sapiens Human PF07679 PF00047 PF13855 PF16920 PF01462 PF07714 7.5 Ki ChEMBL
O95819 MAP4K4 Homo sapiens Human PF00780 PF00069 7.3 Ki ChEMBL
P36888 FLT3 Homo sapiens Human PF00047 PF07714 7.2 Ki ChEMBL
P51451 BLK Homo sapiens Human PF07714 PF00017 PF00018 7.2 Ki ChEMBL
Q13882 PTK6 Homo sapiens Human PF07714 PF00017 PF00018 7.1 Ki ChEMBL
Q06187 BTK Homo sapiens Human PF00779 PF00169 PF07714 PF00017 PF00018 6.9 Ki ChEMBL
Q9H3Y6 SRMS Homo sapiens Human PF07714 PF00017 6.9 Ki ChEMBL
Q12851 MAP4K2 Homo sapiens Human PF00780 PF00069 6.7 Ki ChEMBL
P00533 EGFR Homo sapiens Human PF00757 PF14843 PF07714 PF01030 PF21314 6.6 Ki ChEMBL
P30530 AXL Homo sapiens Human PF00041 PF13927 PF07714 6.6 Ki ChEMBL
P07333 CSF1R Homo sapiens Human PF00047 PF25305 PF07714 6.5 Ki ChEMBL
Q8N4C8 MINK1 Homo sapiens Human PF00780 PF00069 6.4 Ki ChEMBL
Q9HAZ1 CLK4 Homo sapiens Human PF00069 6.4 Ki ChEMBL
Q9NYL2 MAP3K20 Homo sapiens Human PF07714 PF07647 6.4 Ki ChEMBL
P04629 NTRK1 Homo sapiens Human PF13855 PF16920 PF07714 PF18613 6.3 Ki ChEMBL
P16591 FER Homo sapiens Human PF00611 PF07714 PF00017 6.3 Ki ChEMBL
P49841 GSK3B Homo sapiens Human PF00069 6.3 Ki ChEMBL
Q13555 CAMK2G Homo sapiens Human PF08332 PF00069 6.3 Ki ChEMBL
Q7KZI7 MARK2 Homo sapiens Human PF02149 PF00069 PF00627 6.3 Ki ChEMBL
P10721 KIT Homo sapiens Human PF00047 PF07714 6.2 Ki ChEMBL
P45984 MAPK9 Homo sapiens Human PF00069 6.2 Ki ChEMBL
Q06418 TYRO3 Homo sapiens Human PF00041 PF07679 PF07714 6.2 Ki ChEMBL
Q13557 CAMK2D Homo sapiens Human PF08332 PF00069 6.2 Ki ChEMBL
Q14680 MELK Homo sapiens Human PF02149 PF00069 PF21594 6.2 Ki ChEMBL
Q16513 PKN2 Homo sapiens Human PF02185 PF00069 PF00433 6.2 Ki ChEMBL
Q9BZL6 PRKD2 Homo sapiens Human PF00130 PF00169 PF00069 PF25525 6.2 Ki ChEMBL
Q9H4B4 PLK3 Homo sapiens Human PF00069 PF00659 6.2 Ki ChEMBL
Q9HBY8 SGK2 Homo sapiens Human PF00069 PF00433 6.2 Ki ChEMBL
Q9Y4K4 MAP4K5 Homo sapiens Human PF00780 PF00069 6.2 Ki ChEMBL
P27448 MARK3 Homo sapiens Human PF02149 PF00069 PF00627 6.1 Ki ChEMBL
P43405 SYK Homo sapiens Human PF07714 PF00017 6.1 Ki ChEMBL
Q13464 ROCK1 Homo sapiens Human PF25346 PF00069 PF08912 6.1 Ki ChEMBL
Q9H2G2 SLK Homo sapiens Human PF00069 PF12474 6.1 Ki ChEMBL
Q9HBH9 MKNK2 Homo sapiens Human PF00069 6.1 Ki ChEMBL
O94806 PRKD3 Homo sapiens Human PF00130 PF00169 PF00069 PF25525 6.0 Ki ChEMBL
P49840 GSK3A Homo sapiens Human PF00069 6.0 Ki ChEMBL
Q13554 CAMK2B Homo sapiens Human PF08332 PF00069 6.0 Ki ChEMBL
Q5VT25 CDC42BPA Homo sapiens Human PF00130 PF00780 PF08826 PF15796 PF25346 PF00069 PF00433 6.0 Ki ChEMBL
Q9BXA7 TSSK1B Homo sapiens Human PF00069 6.0 Ki ChEMBL
Q9UM73 ALK Homo sapiens Human PF12810 PF00629 PF07714 6.0 Ki ChEMBL