Molecule Details
InChIKeyUSUZGMWDZDXMDG-CYBMUJFWSA-N
Compound NameOsilodrostat
Canonical SMILESN#Cc1ccc([C@H]2CCc3cncn32)c(F)c1
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)3
Pfam Stratification Homologous
Avg pChEMBL8.04
SourceChEMBL;BindingDB
2D Structure
2D structure
Activity Profile
DrugBank Annotations
DrugBank ID DB11837
Drug NameOsilodrostat
CAS Number928134-65-0
Groups approved investigational
ATC Codes H02CA02
DescriptionOsilodrostat is an inhibitor of 11β-hydroxylase (also referred to as CYP11B1), the enzyme that catalyzes the final step in the biosynthesis of endogenous cortisol.[L12123] It is used to lower circulating cortisol levels in the treatment of Cushing's disease, a disorder in which cortisol levels are c...
Categories: Antiadrenal Preparations Anticorticosteroids Cortisol Synthesis Inhibitors Cytochrome P-450 CYP11B2, antagonists & inhibitors Cytochrome P-450 CYP1A2 Inhibitors Cytochrome P-450 CYP1A2 Inhibitors (moderate) Cytochrome P-450 CYP2B6 Substrates Cytochrome P-450 CYP2C19 Inhibitors Cytochrome P-450 CYP2C19 Inhibitors (weak) Cytochrome P-450 CYP2D6 Inhibitors Cytochrome P-450 CYP2D6 Inhibitors (weak) Cytochrome P-450 CYP2D6 Substrates Cytochrome P-450 CYP2E1 Inhibitors Cytochrome P-450 CYP2E1 Inhibitors (strength unknown) Cytochrome P-450 CYP3A Inhibitors Cytochrome P-450 CYP3A Substrates Cytochrome P-450 CYP3A4 Inhibitors Cytochrome P-450 CYP3A4 Inhibitors (weak) Cytochrome P-450 CYP3A4 Substrates Cytochrome P-450 CYP3A5 Inhibitors Cytochrome P-450 CYP3A5 Inhibitors (weak) Cytochrome P-450 Enzyme Inhibitors Cytochrome P-450 Substrates Cytochrome P450 11B1 Inhibitors MATE 1 Inhibitors MATE inhibitors OAT1/SLC22A6 inhibitors OAT3/SLC22A8 Inhibitors OATP1B1/SLCO1B1 Inhibitors OCT1 inhibitors OCT2 Inhibitors Systemic Hormonal Preparations, Excl. Sex Hormones and Insulins UGT1A1 Inhibitors UGT1A4 substrates UGT2B7 substrates
Cross-references: BindingDB: 50444549 CHEMBL3099695 ChemSpider: 29340911 Drugs Product Database (DPD): 27071 PDB: YSY PubChem:44139752 PubChem:347828182 RxCUI: 2286252 Wikipedia: Osilodrostat ZINC: ZINC000072318114
Target Activities (3)
Target Gene Organism Category Pfam pChEMBL Type Source
P19099 CYP11B2 Homo sapiens Human PF00067 9.5 IC50 ChEMBL;BindingDB
P15538 CYP11B1 Homo sapiens Human PF00067 8.5 IC50 ChEMBL;BindingDB
P11511 CYP19A1 Homo sapiens Human PF00067 6.1 IC50 ChEMBL;BindingDB
DrugBank Target Actions (21)
Target Gene Target Name Action Type
P05177 CYP1A2 Cytochrome P450 1A2 inhibitor enzymes
P05181 CYP2E1 Cytochrome P450 2E1 inhibitor enzymes
P08684 CYP3A4 Cytochrome P450 3A4 inhibitor enzymes
P10635 CYP2D6 Cytochrome P450 2D6 inhibitor enzymes
P20815 CYP3A5 Cytochrome P450 3A5 inhibitor enzymes
P22309 UGT1A1 UDP-glucuronosyltransferase 1A1 inhibitor enzymes
P33261 CYP2C19 Cytochrome P450 2C19 inhibitor enzymes
P08684 CYP3A4 Cytochrome P450 3A4 substrate enzymes
P10635 CYP2D6 Cytochrome P450 2D6 substrate enzymes
P16662 UGT2B7 UDP-glucuronosyltransferase 2B7 substrate enzymes
P20813 CYP2B6 Cytochrome P450 2B6 substrate enzymes
P22310 P22310 UDP-glucuronosyltransferase 1A4 substrate enzymes
P36537 P36537 UDP-glucuronosyltransferase 2B10 substrate enzymes
P15538 CYP11B1 Cytochrome P450 11B1, mitochondrial inhibitor targets
P19099 CYP11B2 Cytochrome P450 11B2, mitochondrial inhibitor targets
O15244 SLC22A2 Solute carrier family 22 member 2 inhibitor transporters
O15245 SLC22A1 Solute carrier family 22 member 1 inhibitor transporters
Q4U2R8 SLC22A6 Solute carrier family 22 member 6 inhibitor transporters
Q8TCC7 SLC22A8 Organic anion transporter 3 inhibitor transporters
Q96FL8 SLC47A1 Multidrug and toxin extrusion protein 1 inhibitor transporters
Q9Y6L6 SLCO1B1 Solute carrier organic anion transporter family member 1B1 inhibitor transporters