Molecule Details
InChIKeyUSBKPWRTJAXTBS-UHFFFAOYSA-N
Compound NameMeridianin E
Canonical SMILESNc1nccc(-c2c[nH]c3c(Br)ccc(O)c23)n1
Clinical Status Clinical Multi-Target
Targets (Human+Pathogen)16
Pfam Stratification Cross-Family
Avg pChEMBL6.6
SourceBindingDB;ChEMBL;TTD_MultiTarget
2D Structure
2D structure
Activity Profile
Target Activities (16)
Target Gene Organism Category Pfam pChEMBL Type Source
P17612 PRKACA Homo sapiens Human PF00069 7.0 IC50 ChEMBL
P22612 PRKACG Homo sapiens Human PF00069 7.0 IC50 ChEMBL
P22694 PRKACB Homo sapiens Human PF00069 7.0 IC50 ChEMBL
Q00535 CDK5 Homo sapiens Human PF00069 6.8 IC50 ChEMBL
Q15078 CDK5R1 Homo sapiens Human PF03261 6.8 IC50 ChEMBL;BindingDB
O95067 CCNB2 Homo sapiens Human PF02984 PF00134 6.8 IC50 ChEMBL
P14635 CCNB1 Homo sapiens Human PF02984 PF00134 6.8 IC50 ChEMBL
Q8WWL7 CCNB3 Homo sapiens Human PF02984 PF00134 6.8 IC50 ChEMBL
P06493 CDK1 Homo sapiens Human PF00069 6.7 pIC50 TTD_MultiTarget
P11802 CDK4 Homo sapiens Human PF00069 6.7 pIC50 TTD_MultiTarget
P18505 GABRB1 Homo sapiens Human PF02931 PF02932 6.7 pIC50 TTD_MultiTarget
P24941 CDK2 Homo sapiens Human PF00069 6.4 pIC50 TTD_MultiTarget
P49840 GSK3A Homo sapiens Human PF00069 6.0 IC50 ChEMBL
P45983 MAPK8 Homo sapiens Human PF00069 6.0 IC50 ChEMBL
P45984 MAPK9 Homo sapiens Human PF00069 6.0 IC50 ChEMBL
P53779 MAPK10 Homo sapiens Human PF00069 6.0 IC50 ChEMBL