N-(2,5-difluoro-4-piperazin-1-ylphenyl)-5-fluoro-4-(8-fluoro-4-propan-2-yl-2,3-dihydro-1,4-benzoxazin-6-yl)pyrimidin-2-amine

InChIKey	`UQVXBLAVQKBUCD-UHFFFAOYSA-N`
Compound Name	N-(2,5-difluoro-4-piperazin-1-ylphenyl)-5-fluoro-4-(8-fluoro-4-propan-2-yl-2,3-dihydro-1,4-benzoxazin-6-yl)pyrimidin-2-amine
Canonical SMILES	`CC(C)N1CCOc2c(F)cc(-c3nc(Nc4cc(F)c(N5CCNCC5)cc4F)ncc3F)cc21`
Clinical Status	Data-mined Candidate
Targets (Human+Pathogen)	3
Pfam Stratification	Cross-Family
Avg pChEMBL	7.8
Source	ChEMBL;BindingDB

2D Structure

Activity Profile

Target	Gene	Organism	Category	Pfam	pChEMBL	Type	Source
P11802	CDK4	Homo sapiens	Human	PF00069	8.6	IC50	ChEMBL;BindingDB
Q00534	CDK6	Homo sapiens	Human	PF00069	7.5	IC50	ChEMBL;BindingDB
P07333	CSF1R	Homo sapiens	Human	PF00047 PF25305 PF07714	7.3	IC50	ChEMBL;BindingDB