Molecule Details
InChIKeyUQNNJYLAPYGZBD-UHFFFAOYSA-N
Compound NameN-[4-[4-amino-7-[3-[2-(dimethylamino)ethylamino]-3-oxoprop-1-enyl]thieno[3,2-c]pyridin-3-yl]-2-methoxyphenyl]-1-methylindole-2-carboxamide
Canonical SMILESCOc1cc(-c2csc3c(C=CC(=O)NCCN(C)C)cnc(N)c23)ccc1NC(=O)c1cc2ccccc2n1C
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)28
Pfam Stratification Cross-Family
Avg pChEMBL6.85
SourceChEMBL
2D Structure
2D structure
Activity Profile
Target Activities (28)
Target Gene Organism Category Pfam pChEMBL Type Source
P06241 FYN Homo sapiens Human PF07714 PF00017 PF00018 8.4 Ki ChEMBL
P06239 LCK Homo sapiens Human PF07714 PF00017 PF00018 8.1 Ki ChEMBL
P00519 ABL1 Homo sapiens Human PF08919 PF07714 PF00017 PF00018 7.9 Ki ChEMBL
Q06187 BTK Homo sapiens Human PF00779 PF00169 PF07714 PF00017 PF00018 7.9 Ki ChEMBL
P09619 PDGFRB Homo sapiens Human PF00047 PF13927 PF25305 PF07714 7.5 Ki ChEMBL
P16234 PDGFRA Homo sapiens Human PF07679 PF25305 PF07714 7.4 Ki ChEMBL
Q96GD4 AURKB Homo sapiens Human PF00069 7.4 Ki ChEMBL
P36507 MAP2K2 Homo sapiens Human PF00069 7.2 Ki ChEMBL
P53667 LIMK1 Homo sapiens Human PF00412 PF00595 PF07714 7.2 Ki ChEMBL
P07333 CSF1R Homo sapiens Human PF00047 PF25305 PF07714 7.1 Ki ChEMBL
Q02750 MAP2K1 Homo sapiens Human PF00069 6.9 Ki ChEMBL
Q06418 TYRO3 Homo sapiens Human PF00041 PF07679 PF07714 6.9 Ki ChEMBL
Q07912 TNK2 Homo sapiens Human PF09027 PF11555 PF07714 PF22931 PF14604 6.8 Ki ChEMBL
O14965 AURKA Homo sapiens Human PF00069 6.7 Ki ChEMBL
O95819 MAP4K4 Homo sapiens Human PF00780 PF00069 6.6 Ki ChEMBL
P08581 MET Homo sapiens Human PF07714 PF01437 PF01403 PF01833 6.5 Ki ChEMBL
P51955 NEK2 Homo sapiens Human PF00069 6.5 Ki ChEMBL
O94806 PRKD3 Homo sapiens Human PF00130 PF00169 PF00069 PF25525 6.4 Ki ChEMBL
P51817 PRKX Homo sapiens Human PF00069 6.4 Ki ChEMBL
Q12851 MAP4K2 Homo sapiens Human PF00780 PF00069 6.4 Ki ChEMBL
P35968 KDR Homo sapiens Human PF07679 PF00047 PF13895 PF22971 PF07714 PF21339 PF17988 PF22854 6.3 Ki ChEMBL
P36888 FLT3 Homo sapiens Human PF00047 PF07714 6.3 Ki ChEMBL
Q13464 ROCK1 Homo sapiens Human PF25346 PF00069 PF08912 6.3 Ki ChEMBL
Q13131 PRKAA1 Homo sapiens Human PF16579 PF21147 PF00069 6.2 Ki ChEMBL
Q14164 IKBKE Homo sapiens Human PF00069 PF18394 PF18396 6.2 Ki ChEMBL
Q00535 CDK5 Homo sapiens Human PF00069 6.1 Ki ChEMBL
Q04912 MST1R Homo sapiens Human PF07714 PF01437 PF01403 PF01833 6.1 Ki ChEMBL
Q16620 NTRK2 Homo sapiens Human PF07679 PF13855 PF16920 PF01462 PF07714 6.0 Ki ChEMBL