Molecule Details
InChIKeyUQJQNZHGEVLHST-UHFFFAOYSA-N
Compound Name1-(6-Bromo-2-pyridinyl)-3-(7-methoxyquinolin-4-yl)urea
Canonical SMILESCOc1ccc2c(NC(=O)Nc3cccc(Br)n3)ccnc2c1
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)15
Pfam Stratification Cross-Family
Avg pChEMBL7.33
SourceChEMBL
2D Structure
2D structure
Activity Profile
Target Activities (15)
Target Gene Organism Category Pfam pChEMBL Type Source
Q9HAZ1 CLK4 Homo sapiens Human PF00069 8.3 Ki ChEMBL
Q9H2X6 HIPK2 Homo sapiens Human PF00069 8.2 Ki ChEMBL
Q8NE63 HIPK4 Homo sapiens Human PF00069 8.1 Ki ChEMBL
O95819 MAP4K4 Homo sapiens Human PF00780 PF00069 8.0 Ki ChEMBL
Q96GD4 AURKB Homo sapiens Human PF00069 7.9 Ki ChEMBL
Q13882 PTK6 Homo sapiens Human PF07714 PF00017 PF00018 7.8 Ki ChEMBL
P08922 ROS1 Homo sapiens Human PF00041 PF07714 7.6 Ki ChEMBL
P35968 KDR Homo sapiens Human PF07679 PF00047 PF13895 PF22971 PF07714 PF21339 PF17988 PF22854 7.6 Ki ChEMBL
Q9UEE5 STK17A Homo sapiens Human PF00069 7.4 Ki ChEMBL
Q9Y4K4 MAP4K5 Homo sapiens Human PF00780 PF00069 7.3 Ki ChEMBL
P36888 FLT3 Homo sapiens Human PF00047 PF07714 7.0 Ki ChEMBL
Q13627 DYRK1A Homo sapiens Human PF00069 6.6 Ki ChEMBL
P24941 CDK2 Homo sapiens Human PF00069 6.1 Ki ChEMBL
P49760 CLK2 Homo sapiens Human PF00069 6.1 Ki ChEMBL
Q13131 PRKAA1 Homo sapiens Human PF16579 PF21147 PF00069 6.0 Ki ChEMBL