Molecule Details
InChIKeyUPTQSRGSSJRBKJ-LJQANCHMSA-N
Compound Name6,7-Dimethoxy-4-[(3R)-3-(2-naphthyloxy)pyrrolidin-1-YL]quinazoline
Canonical SMILESCOc1cc2ncnc(N3CC[C@@H](Oc4ccc5ccccc5c4)C3)c2cc1OC
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)3
Pfam Stratification Homologous
Avg pChEMBL6.93
SourceChEMBL;BindingDB
2D Structure
2D structure
Activity Profile
DrugBank Annotations
DrugBank ID DB08389
Drug Name6,7-DIMETHOXY-4-[(3R)-3-(2-NAPHTHYLOXY)PYRROLIDIN-1-YL]QUINAZOLINE
CAS Numbernan
Groups experimental
ATC Codes nan
Descriptionnan
Cross-references: BindingDB: 14760 CHEMBL410834 ChemSpider: 13122521 PDB: PFH PubChem:15991588 PubChem:99444860 ZINC: ZINC000014956477
Target Activities (3)
Target Gene Organism Category Pfam pChEMBL Type Source
Q9Y233 PDE10A Homo sapiens Human PF01590 PF00233 7.9 Ki ChEMBL;BindingDB
Q14432 PDE3A Homo sapiens Human PF00233 6.5 Ki ChEMBL;BindingDB
Q13370 PDE3B Homo sapiens Human PF00233 6.3 Ki ChEMBL;BindingDB
DrugBank Target Actions (1)
Target Gene Target Name Action Type
Q9Y233 PDE10A cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A binder targets