Molecule Details
| InChIKey | UPNUIXSCZBYVBB-JVFUWBCBSA-N |
|---|---|
| Compound Name | Alvimopan |
| Canonical SMILES | C[C@H]1CN(C[C@H](Cc2ccccc2)C(=O)NCC(=O)O)CC[C@@]1(C)c1cccc(O)c1 |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 3 |
| Pfam Stratification | Homologous |
| Avg pChEMBL | 8.02 |
| Source | ChEMBL;BindingDB |
2D Structure
Activity Profile
DrugBank Annotations
| DrugBank ID | DB06274 |
|---|---|
| Drug Name | Alvimopan |
| CAS Number | 156053-89-3 |
| Groups | approved investigational |
| ATC Codes | A06AH02 |
| Description | Alvimopan is a peripherally acting μ opioid antagonist. It is used to avoid postoperative ileus following small or large bowel resection and accelerates the gastrointestinal recovery period. |
Categories: Alimentary Tract and Metabolism Drugs for Constipation Gastrointestinal Agents Opioid Antagonists Peripheral Opioid Receptor Antagonists Receptors, Opioid, mu, antagonists & inhibitors
Cross-references: BindingDB: 50088381 ChEBI: 135686 CHEMBL270190 ChemSpider: 4589864 D02878 PDB: NG0 PharmGKB: PA164754864 PubChem:5488548 PubChem:99443242 RxCUI: 480639 Therapeutic Targets Database: DAP001140 Wikipedia: Alvimopan ZINC: ZINC000003802417