Molecule Details
| InChIKey | UPBPVAZUFAXUAC-UHFFFAOYSA-N |
|---|---|
| Compound Name | 2-Methyl-4-[6-(4-piperidin-4-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline |
| Canonical SMILES | Cc1cc(-c2cnn3cc(-c4ccc(C5CCNCC5)cc4)cnc23)c2ccccc2n1 |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 6 |
| Pfam Stratification | Homologous |
| Avg pChEMBL | 7.29 |
| Source | BindingDB;ChEMBL |
2D Structure
Activity Profile
Target Activities (6)
| Target | Gene | Organism | Category | Pfam | pChEMBL | Type | Source |
|---|---|---|---|---|---|---|---|
| P37023 | ACVRL1 | Homo sapiens | Human | PF07714 PF08515 | 7.8 | IC50 | ChEMBL;BindingDB |
| Q04771 | ACVR1 | Homo sapiens | Human | PF01064 PF07714 PF08515 | 7.6 | IC50 | ChEMBL;BindingDB |
| P36894 | BMPR1A | Homo sapiens | Human | PF01064 PF07714 PF08515 | 7.5 | IC50 | ChEMBL;BindingDB |
| O00238 | BMPR1B | Homo sapiens | Human | PF01064 PF07714 PF08515 | 7.3 | IC50 | ChEMBL;BindingDB |
| P36896 | ACVR1B | Homo sapiens | Human | PF01064 PF00069 PF08515 | 6.9 | IC50 | ChEMBL;BindingDB |
| P36897 | TGFBR1 | Homo sapiens | Human | PF01064 PF00069 PF08515 | 6.6 | IC50 | BindingDB |