Molecule Details
| InChIKey | UOWZUVNAGUAEQC-UHFFFAOYSA-N |
|---|---|
| Compound Name | Tiratricol |
| Canonical SMILES | O=C(O)Cc1cc(I)c(Oc2ccc(O)c(I)c2)c(I)c1 |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 3 |
| Pfam Stratification | Homologous |
| Avg pChEMBL | 8.96 |
| Source | ChEMBL;BindingDB |
2D Structure
Activity Profile
DrugBank Annotations
| DrugBank ID | DB03604 |
|---|---|
| Drug Name | Tiratricol |
| CAS Number | 51-24-1 |
| Groups | approved investigational |
| ATC Codes | H03AA04 D11AX08 |
| Description | Tiratricol is an analogue and active metabolite of the thyroid hormone triiodothyronine (T3).[L53383] It was first approved by the EMA on February 12, 2025 for the treatment of peripheral thyrotoxicosis in patients with monocarboxylate transporter 8 (MCT8) deficiency,[A274038] a disorder characteriz... |
Categories: Agents used to treat hypothyroidism Amino Acids Amino Acids, Aromatic Amino Acids, Cyclic Amino Acids, Peptides, and Proteins Cytochrome P-450 CYP3A Inducers Cytochrome P-450 CYP3A4 Inducers Cytochrome P-450 CYP3A4 Inducers (strength unknown) Cytochrome P-450 Enzyme Inducers Dermatologicals Hormones Hormones, Hormone Substitutes, and Hormone Antagonists NTCP Inhibitors Systemic Hormonal Preparations, Excl. Sex Hormones and Insulins Thyroid Products Thyronines
Cross-references: BindingDB: 18862 CHEMBL41632 ChemSpider: 5598 Guide to Pharmacology: 2637 IUPHAR: 2637 PDB: 4HY PubChem:5803 PubChem:46504696 RxCUI: 13982 Wikipedia: Tiratricol ZINC: ZINC000004217580
Target Activities (3)
DrugBank Target Actions (5)
| Target | Gene | Target Name | Action | Type |
|---|---|---|---|---|
| P08684 | CYP3A4 | Cytochrome P450 3A4 | inducer | enzymes |
| P10827 | THRA | Thyroid hormone receptor alpha | agonist | targets |
| P10828 | THRB | Thyroid hormone receptor beta | agonist | targets |
| Q02127 | DHODH | Dihydroorotate dehydrogenase (quinone), mitochondrial | inhibitor | targets |
| Q14973 | SLC10A1 | Hepatic sodium/bile acid cotransporter | inhibitor | transporters |