Molecule Details
InChIKeyUOVCGJXDGOGOCZ-UHFFFAOYSA-N
Compound NameR-1530
Canonical SMILESCOc1cc2c(cc1F)C(c1ccccc1Cl)=Nc1c(n[nH]c1C)N2
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)59
Pfam Stratification Cross-Family
Avg pChEMBL6.89
SourceChEMBL;BindingDB
2D Structure
2D structure
Activity Profile
Target Activities (59)
Target Gene Organism Category Pfam pChEMBL Type Source
P35968 KDR Homo sapiens Human PF07679 PF00047 PF13895 PF22971 PF07714 PF21339 PF17988 PF22854 8.0 IC50 ChEMBL;BindingDB
O00444 PLK4 Homo sapiens Human PF00069 PF18190 PF18409 8.0 Ki ChEMBL;BindingDB
P07949 RET Homo sapiens Human PF00028 PF07714 PF17756 PF17812 PF17813 PF22540 7.9 Ki ChEMBL
Q05397 PTK2 Homo sapiens Human PF21477 PF00373 PF18038 PF03623 PF07714 7.9 Ki ChEMBL
P08922 ROS1 Homo sapiens Human PF00041 PF07714 7.7 Ki ChEMBL
P49841 GSK3B Homo sapiens Human PF00069 7.7 Ki ChEMBL
O96017 CHEK2 Homo sapiens Human PF00498 PF00069 7.6 IC50 ChEMBL;BindingDB
P22607 FGFR3 Homo sapiens Human PF21165 PF07679 PF13927 PF07714 7.6 Ki ChEMBL
P11362 FGFR1 Homo sapiens Human PF07679 PF00047 PF07714 7.5 IC50 ChEMBL;BindingDB
Q9Y463 DYRK1B Homo sapiens Human PF00069 7.5 Ki ChEMBL
Q04912 MST1R Homo sapiens Human PF07714 PF01437 PF01403 PF01833 7.4 Ki ChEMBL
Q13188 STK3 Homo sapiens Human PF11629 PF00069 7.4 Ki ChEMBL
Q9H2G2 SLK Homo sapiens Human PF00069 PF12474 7.4 Ki ChEMBL
O15530 PDPK1 Homo sapiens Human PF14593 PF00069 7.3 Ki ChEMBL
P09619 PDGFRB Homo sapiens Human PF00047 PF13927 PF25305 PF07714 7.3 Ki ChEMBL
P17948 FLT1 Homo sapiens Human PF07679 PF00047 PF13927 PF22971 PF07714 PF21339 PF17988 PF22854 7.3 Ki ChEMBL
P29317 EPHA2 Homo sapiens Human PF14575 PF25599 PF01404 PF00041 PF07714 PF00536 7.3 Ki ChEMBL
P29597 TYK2 Homo sapiens Human PF18379 PF18377 PF17887 PF07714 PF21990 7.3 Ki ChEMBL
P49840 GSK3A Homo sapiens Human PF00069 7.3 Ki ChEMBL
O14965 AURKA Homo sapiens Human PF00069 7.2 IC50 ChEMBL;BindingDB
P51451 BLK Homo sapiens Human PF07714 PF00017 PF00018 7.2 Ki ChEMBL
O96013 PAK4 Homo sapiens Human PF00786 PF00069 7.1 Ki ChEMBL
P36888 FLT3 Homo sapiens Human PF00047 PF07714 7.1 Ki ChEMBL
P42685 FRK Homo sapiens Human PF07714 PF00017 PF00018 7.1 Ki ChEMBL
P52333 JAK3 Homo sapiens Human PF18379 PF18377 PF17887 PF07714 PF21990 7.1 Ki ChEMBL
Q16288 NTRK3 Homo sapiens Human PF07679 PF00047 PF13855 PF16920 PF01462 PF07714 7.0 Ki ChEMBL
Q16620 NTRK2 Homo sapiens Human PF07679 PF13855 PF16920 PF01462 PF07714 7.0 Ki ChEMBL
O60674 JAK2 Homo sapiens Human PF18379 PF18377 PF17887 PF07714 PF21990 6.9 Ki ChEMBL
P12931 SRC Homo sapiens Human PF07714 PF00017 PF00018 6.9 Ki ChEMBL
P16591 FER Homo sapiens Human PF00611 PF07714 PF00017 6.9 Ki ChEMBL
Q08881 ITK Homo sapiens Human PF00779 PF00169 PF07714 PF00017 PF00018 6.9 Ki ChEMBL
Q5S007 LRRK2 Homo sapiens Human PF23745 PF23744 PF23748 PF16095 PF25497 PF13855 PF00069 PF08477 6.9 Ki ChEMBL
P24941 CDK2 Homo sapiens Human PF00069 6.8 Ki ChEMBL
P43405 SYK Homo sapiens Human PF07714 PF00017 6.8 Ki ChEMBL
P51812 RPS6KA3 Homo sapiens Human PF00069 PF00433 6.8 Ki ChEMBL
Q00535 CDK5 Homo sapiens Human PF00069 6.8 Ki ChEMBL
P07948 LYN Homo sapiens Human PF07714 PF00017 PF00018 6.7 Ki ChEMBL
P10721 KIT Homo sapiens Human PF00047 PF07714 6.7 Ki ChEMBL
Q06187 BTK Homo sapiens Human PF00779 PF00169 PF07714 PF00017 PF00018 6.7 Ki ChEMBL
Q04771 ACVR1 Homo sapiens Human PF01064 PF07714 PF08515 6.6 Ki ChEMBL
P06241 FYN Homo sapiens Human PF07714 PF00017 PF00018 6.5 Ki ChEMBL
P16234 PDGFRA Homo sapiens Human PF07679 PF25305 PF07714 6.5 Ki ChEMBL
Q13153 PAK1 Homo sapiens Human PF00786 PF00069 6.5 Ki ChEMBL
Q12851 MAP4K2 Homo sapiens Human PF00780 PF00069 6.4 Ki ChEMBL
O14757 CHEK1 Homo sapiens Human PF00069 6.3 Ki ChEMBL
P06213 INSR Homo sapiens Human PF00757 PF17870 PF07714 PF01030 6.3 Ki ChEMBL
P53667 LIMK1 Homo sapiens Human PF00412 PF00595 PF07714 6.3 Ki ChEMBL
P50613 CDK7 Homo sapiens Human PF00069 6.2 Ki ChEMBL
P51617 IRAK1 Homo sapiens Human PF00531 PF00069 6.2 Ki ChEMBL
Q13131 PRKAA1 Homo sapiens Human PF16579 PF21147 PF00069 6.2 Ki ChEMBL
P04629 NTRK1 Homo sapiens Human PF13855 PF16920 PF07714 PF18613 6.1 Ki ChEMBL
P06239 LCK Homo sapiens Human PF07714 PF00017 PF00018 6.1 Ki ChEMBL
P06493 CDK1 Homo sapiens Human PF00069 6.1 Ki ChEMBL
P07333 CSF1R Homo sapiens Human PF00047 PF25305 PF07714 6.1 Ki ChEMBL
P34947 GRK5 Homo sapiens Human PF00069 PF00615 6.1 Ki ChEMBL
Q16539 MAPK14 Homo sapiens Human PF00069 6.1 Ki ChEMBL
Q9NWZ3 IRAK4 Homo sapiens Human PF07714 6.1 Ki ChEMBL
Q96PF2 TSSK2 Homo sapiens Human PF00069 6.0 Ki ChEMBL
Q9HAZ1 CLK4 Homo sapiens Human PF00069 6.0 Ki ChEMBL