Molecule Details
InChIKeyUMTWTCVTRDYHQQ-UHFFFAOYSA-N
Compound Name1-[[5-(3-methyl-2H-pyrazolo[3,4-c]pyridin-5-yl)-3-pyridinyl]oxy]-3-[3-(trifluoromethyl)phenyl]propan-2-amine
Canonical SMILESCc1n[nH]c2cnc(-c3cncc(OCC(N)Cc4cccc(C(F)(F)F)c4)c3)cc12
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)56
Pfam Stratification Cross-Family
Avg pChEMBL7.17
SourceChEMBL
2D Structure
2D structure
Activity Profile
Target Activities (56)
Target Gene Organism Category Pfam pChEMBL Type Source
Q9P1W9 PIM2 Homo sapiens Human PF00069 8.9 Ki ChEMBL
O43293 DAPK3 Homo sapiens Human PF00069 8.4 Ki ChEMBL
Q8N4C8 MINK1 Homo sapiens Human PF00780 PF00069 8.4 Ki ChEMBL
Q13557 CAMK2D Homo sapiens Human PF08332 PF00069 8.3 Ki ChEMBL
P31751 AKT2 Homo sapiens Human PF00169 PF00069 PF00433 8.2 Ki ChEMBL
Q13464 ROCK1 Homo sapiens Human PF25346 PF00069 PF08912 8.1 Ki ChEMBL
O00311 CDC7 Homo sapiens Human PF00069 8.0 Ki ChEMBL
P24941 CDK2 Homo sapiens Human PF00069 8.0 Ki ChEMBL
Q13555 CAMK2G Homo sapiens Human PF08332 PF00069 8.0 Ki ChEMBL
P23443 RPS6KB1 Homo sapiens Human PF00069 PF00433 7.9 Ki ChEMBL
P49336 CDK8 Homo sapiens Human PF00069 7.9 Ki ChEMBL
Q13131 PRKAA1 Homo sapiens Human PF16579 PF21147 PF00069 7.9 Ki ChEMBL
P51812 RPS6KA3 Homo sapiens Human PF00069 PF00433 7.8 Ki ChEMBL
Q13976 PRKG1 Homo sapiens Human PF00027 PF16808 PF00069 7.8 Ki ChEMBL
Q14680 MELK Homo sapiens Human PF02149 PF00069 PF21594 7.8 Ki ChEMBL
O75116 ROCK2 Homo sapiens Human PF25346 PF00069 PF08912 7.7 Ki ChEMBL
Q16513 PKN2 Homo sapiens Human PF02185 PF00069 PF00433 7.6 Ki ChEMBL
Q8NE63 HIPK4 Homo sapiens Human PF00069 7.6 Ki ChEMBL
P06493 CDK1 Homo sapiens Human PF00069 7.5 Ki ChEMBL
Q13237 PRKG2 Homo sapiens Human PF00027 PF00069 7.5 Ki ChEMBL
Q7L7X3 TAOK1 Homo sapiens Human PF00069 7.5 Ki ChEMBL
Q9BXA7 TSSK1B Homo sapiens Human PF00069 7.5 Ki ChEMBL
P27448 MARK3 Homo sapiens Human PF02149 PF00069 PF00627 7.2 Ki ChEMBL
Q00535 CDK5 Homo sapiens Human PF00069 7.2 Ki ChEMBL
Q12851 MAP4K2 Homo sapiens Human PF00780 PF00069 7.2 Ki ChEMBL
Q9HBY8 SGK2 Homo sapiens Human PF00069 PF00433 7.2 Ki ChEMBL
Q9HCP0 CSNK1G1 Homo sapiens Human PF12605 PF00069 7.2 Ki ChEMBL
O75582 RPS6KA5 Homo sapiens Human PF00069 PF00433 7.1 Ki ChEMBL
O96017 CHEK2 Homo sapiens Human PF00498 PF00069 7.1 Ki ChEMBL
Q13188 STK3 Homo sapiens Human PF11629 PF00069 7.1 Ki ChEMBL
Q7KZI7 MARK2 Homo sapiens Human PF02149 PF00069 PF00627 7.1 Ki ChEMBL
Q96PF2 TSSK2 Homo sapiens Human PF00069 7.1 Ki ChEMBL
Q9Y4K4 MAP4K5 Homo sapiens Human PF00780 PF00069 7.1 Ki ChEMBL
Q9Y6M4 CSNK1G3 Homo sapiens Human PF12605 PF00069 7.1 Ki ChEMBL
Q13554 CAMK2B Homo sapiens Human PF08332 PF00069 7.0 Ki ChEMBL
Q9NR20 DYRK4 Homo sapiens Human PF00069 6.9 Ki ChEMBL
P78368 CSNK1G2 Homo sapiens Human PF12605 PF00069 6.8 Ki ChEMBL
O15530 PDPK1 Homo sapiens Human PF14593 PF00069 6.7 Ki ChEMBL
Q9H2G2 SLK Homo sapiens Human PF00069 PF12474 6.7 Ki ChEMBL
P41743 PRKCI Homo sapiens Human PF00130 PF00564 PF00069 PF00433 6.6 Ki ChEMBL
Q9BZL6 PRKD2 Homo sapiens Human PF00130 PF00169 PF00069 PF25525 6.6 Ki ChEMBL
P48730 CSNK1D Homo sapiens Human PF00069 6.5 Ki ChEMBL
P51617 IRAK1 Homo sapiens Human PF00531 PF00069 6.5 Ki ChEMBL
P51957 NEK4 Homo sapiens Human PF00069 6.5 Ki ChEMBL
O96013 PAK4 Homo sapiens Human PF00786 PF00069 6.4 Ki ChEMBL
P08922 ROS1 Homo sapiens Human PF00041 PF07714 6.4 Ki ChEMBL
Q05513 PRKCZ Homo sapiens Human PF00130 PF00564 PF00069 PF00433 6.4 Ki ChEMBL
Q9NWZ3 IRAK4 Homo sapiens Human PF07714 6.4 Ki ChEMBL
Q14012 CAMK1 Homo sapiens Human PF00069 6.3 Ki ChEMBL
Q9UEE5 STK17A Homo sapiens Human PF00069 6.3 Ki ChEMBL
P28482 MAPK1 Homo sapiens Human PF00069 6.2 Ki ChEMBL
Q96SB4 SRPK1 Homo sapiens Human PF00069 6.2 Ki ChEMBL
Q9HBH9 MKNK2 Homo sapiens Human PF00069 6.2 Ki ChEMBL
O15075 DCLK1 Homo sapiens Human PF03607 PF00069 6.1 Ki ChEMBL
P68400 CSNK2A1 Homo sapiens Human PF00069 6.1 Ki ChEMBL
P53778 MAPK12 Homo sapiens Human PF00069 6.0 Ki ChEMBL