1-[4-[4-Amino-7-[1-(2-hydroxyethyl)pyrazol-4-yl]thieno[3,2-c]pyridin-3-yl]phenyl]-3-(4-methoxyphenyl)urea

InChIKey	`ULMCFLZUGRSEQA-UHFFFAOYSA-N`
Compound Name	1-[4-[4-Amino-7-[1-(2-hydroxyethyl)pyrazol-4-yl]thieno[3,2-c]pyridin-3-yl]phenyl]-3-(4-methoxyphenyl)urea
Canonical SMILES	`COc1ccc(NC(=O)Nc2ccc(-c3csc4c(-c5cnn(CCO)c5)cnc(N)c34)cc2)cc1`
Clinical Status	Data-mined Candidate
Targets (Human+Pathogen)	17
Pfam Stratification	Cross-Family
Avg pChEMBL	8.21
Source	ChEMBL

2D Structure

Activity Profile

Target	Gene	Organism	Category	Pfam	pChEMBL	Type	Source
P00519	ABL1	Homo sapiens	Human	PF08919 PF07714 PF00017 PF00018	9.6	Ki	ChEMBL
Q16288	NTRK3	Homo sapiens	Human	PF07679 PF00047 PF13855 PF16920 PF01462 PF07714	9.1	Ki	ChEMBL
P51451	BLK	Homo sapiens	Human	PF07714 PF00017 PF00018	8.9	Ki	ChEMBL
P07948	LYN	Homo sapiens	Human	PF07714 PF00017 PF00018	8.8	Ki	ChEMBL
P10721	KIT	Homo sapiens	Human	PF00047 PF07714	8.8	Ki	ChEMBL
P08581	MET	Homo sapiens	Human	PF07714 PF01437 PF01403 PF01833	8.5	Ki	ChEMBL
P30530	AXL	Homo sapiens	Human	PF00041 PF13927 PF07714	8.5	Ki	ChEMBL
P06241	FYN	Homo sapiens	Human	PF07714 PF00017 PF00018	8.2	Ki	ChEMBL
P16591	FER	Homo sapiens	Human	PF00611 PF07714 PF00017	8.2	Ki	ChEMBL
P12931	SRC	Homo sapiens	Human	PF07714 PF00017 PF00018	8.1	Ki	ChEMBL
Q13188	STK3	Homo sapiens	Human	PF11629 PF00069	7.9	Ki	ChEMBL
P42685	FRK	Homo sapiens	Human	PF07714 PF00017 PF00018	7.8	Ki	ChEMBL
P04629	NTRK1	Homo sapiens	Human	PF13855 PF16920 PF07714 PF18613	7.7	Ki	ChEMBL
P11362	FGFR1	Homo sapiens	Human	PF07679 PF00047 PF07714	7.7	Ki	ChEMBL
P06213	INSR	Homo sapiens	Human	PF00757 PF17870 PF07714 PF01030	7.6	Ki	ChEMBL
Q16620	NTRK2	Homo sapiens	Human	PF07679 PF13855 PF16920 PF01462 PF07714	7.6	Ki	ChEMBL
Q06187	BTK	Homo sapiens	Human	PF00779 PF00169 PF07714 PF00017 PF00018	6.6	Ki	ChEMBL