N-[4-[[7-[2-(azetidin-1-yl)-2-oxoethyl]-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-4-yl]oxy]-3-fluorophenyl]-3-(4-fluorophenyl)-2,4-dioxo-1-propan-2-ylpyrimidine-5-carboxamide

InChIKey	`ULIRDGCRHUZAAA-UHFFFAOYSA-N`
Compound Name	N-[4-[[7-[2-(azetidin-1-yl)-2-oxoethyl]-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-4-yl]oxy]-3-fluorophenyl]-3-(4-fluorophenyl)-2,4-dioxo-1-propan-2-ylpyrimidine-5-carboxamide
Canonical SMILES	`CC(C)n1cc(C(=O)Nc2ccc(Oc3ncnc4c3CCN(CC(=O)N3CCC3)C4)c(F)c2)c(=O)n(-c2ccc(F)cc2)c1=O`
Clinical Status	Data-mined Candidate
Targets (Human+Pathogen)	2
Pfam Stratification	Homologous
Avg pChEMBL	7.28
Source	ChEMBL;BindingDB

2D Structure

Activity Profile

Target	Gene	Organism	Category	Pfam	pChEMBL	Type	Source
P30530	AXL	Homo sapiens	Human	PF00041 PF13927 PF07714	7.8	IC50	ChEMBL;BindingDB
Q12866	MERTK	Homo sapiens	Human	PF00041 PF00047 PF13927 PF07714	6.7	IC50	ChEMBL;BindingDB