Molecule Details
| InChIKey | UJKFLFOBPZHDJN-UHFFFAOYSA-N |
|---|---|
| Compound Name | 6-(2-chloro-3,5-dimethoxyphenyl)-N-(1,2,3,4-tetrahydroisoquinolin-6-yl)-[1, 2,4]triazolo[4',3':1,6]pyrido[2,3-d]pyri-midin-2-amine |
| Canonical SMILES | COc1cc(OC)c(Cl)c(-c2cc3cnc(Nc4ccc5c(c4)CCNC5)nc3n3cnnc23)c1 |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 3 |
| Pfam Stratification | Homologous |
| Avg pChEMBL | 8.63 |
| Source | ChEMBL;BindingDB |
2D Structure
Activity Profile
Target Activities (3)
| Target | Gene | Organism | Category | Pfam | pChEMBL | Type | Source |
|---|---|---|---|---|---|---|---|
| P11362 | FGFR1 | Homo sapiens | Human | PF07679 PF00047 PF07714 | 9.2 | IC50 | ChEMBL;BindingDB |
| P35968 | KDR | Homo sapiens | Human | PF07679 PF00047 PF13895 PF22971 PF07714 PF21339 PF17988 PF22854 | 8.8 | IC50 | ChEMBL;BindingDB |
| P22455 | FGFR4 | Homo sapiens | Human | PF07679 PF13927 PF07714 | 7.8 | IC50 | ChEMBL;BindingDB |