Molecule Details
| InChIKey | UIEATEWHFDRYRU-UHFFFAOYSA-N |
|---|---|
| Compound Name | Bepridil |
| Canonical SMILES | CC(C)COCC(CN(Cc1ccccc1)c1ccccc1)N1CCCC1 |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 8 |
| Pfam Stratification | Homologous |
| Avg pChEMBL | 6.07 |
| Source | ChEMBL |
2D Structure
Activity Profile
DrugBank Annotations
| DrugBank ID | DB01244 |
|---|---|
| Drug Name | Bepridil |
| CAS Number | 64706-54-3 |
| Groups | approved investigational withdrawn |
| ATC Codes | C08EA02 |
| Description | A long-acting, non selective, calcium channel blocker with significant anti-anginal activity. The drug produces significant coronary vasodilation and modest peripheral effects. It has antihypertensive and selective anti-arrhythmia activities and acts as a calmodulin antagonist. It is no longer marke... |
Categories: Agents causing hyperkalemia Antiarrhythmic agents Antihypertensive Agents Bradycardia-Causing Agents Calcium Channel Blockers Calcium-Regulating Hormones and Agents Cardiovascular Agents Cytochrome P-450 CYP2D6 Inhibitors Cytochrome P-450 CYP2D6 Inhibitors (strength unknown) Cytochrome P-450 CYP2D6 Substrates Cytochrome P-450 CYP3A Substrates Cytochrome P-450 CYP3A4 Substrates Cytochrome P-450 Enzyme Inhibitors Cytochrome P-450 Substrates Highest Risk QTc-Prolonging Agents Hypotensive Agents Membrane Transport Modulators Non-Selective Calcium Channel Blockers P-glycoprotein inhibitors Phenylalkylamine Derivatives Pyrrolidines QTc Prolonging Agents Vasodilating Agents
Cross-references: BindingDB: 78577 ChEBI: 3061 CHEMBL1008 ChemSpider: 2261 Guide to Pharmacology: 2337 IUPHAR: 2337 C06847 D07520 PDB: BEP PharmGKB: PA164754755 PubChem:2351 PubChem:46506353 RxCUI: 1436 Therapeutic Targets Database: DAP000525 Wikipedia: Bepridil
Target Activities (8)
| Target | Gene | Organism | Category | Pfam | pChEMBL | Type | Source |
|---|---|---|---|---|---|---|---|
| Q12809 | KCNH2 | Homo sapiens | Human | PF00027 PF00520 PF13426 | 6.3 | IC50 | ChEMBL |
| P35498 | SCN1A | Homo sapiens | Human | PF00520 PF24609 PF06512 PF11933 | 6.1 | IC50 | ChEMBL |
| Q99250 | SCN2A | Homo sapiens | Human | PF00520 PF24609 PF06512 PF11933 | 6.1 | IC50 | ChEMBL |
| Q9NY46 | SCN3A | Homo sapiens | Human | PF00520 PF24609 PF06512 PF11933 | 6.1 | IC50 | ChEMBL |
| O60840 | CACNA1F | Homo sapiens | Human | PF08763 PF16885 PF16905 PF00520 | 6.0 | IC50 | ChEMBL |
| Q01668 | CACNA1D | Homo sapiens | Human | PF08763 PF16885 PF16905 PF00520 | 6.0 | IC50 | ChEMBL |
| Q13698 | CACNA1S | Homo sapiens | Human | PF08763 PF16905 PF00520 | 6.0 | IC50 | ChEMBL |
| Q13936 | CACNA1C | Homo sapiens | Human | PF08763 PF16885 PF16905 PF00520 | 6.0 | IC50 | ChEMBL |
DrugBank Target Actions (14)
| Target | Gene | Target Name | Action | Type |
|---|---|---|---|---|
| P10635 | CYP2D6 | Cytochrome P450 2D6 | inhibitor | enzymes |
| P08684 | CYP3A4 | Cytochrome P450 3A4 | substrate | enzymes |
| P10635 | CYP2D6 | Cytochrome P450 2D6 | substrate | enzymes |
| P0DP23 | CALM1 | Calmodulin | binder | targets |
| O00555 | CACNA1A | Voltage-dependent P/Q-type calcium channel subunit alpha-1A | inhibitor | targets |
| O95180 | CACNA1H | Voltage-dependent T-type calcium channel subunit alpha-1H | inhibitor | targets |
| P05023 | ATP1A1 | Sodium/potassium-transporting ATPase subunit alpha-1 | inhibitor | targets |
| P51787 | KCNQ1 | Potassium voltage-gated channel subfamily KQT member 1 | inhibitor | targets |
| P54750 | PDE1A | Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A | inhibitor | targets |
| Q01064 | PDE1B | Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B | inhibitor | targets |
| Q12809 | KCNH2 | Voltage-gated inwardly rectifying potassium channel KCNH2 | inhibitor | targets |
| Q9NY47 | CACNA2D2 | Voltage-dependent calcium channel subunit alpha-2/delta-2 | inhibitor | targets |
| P63316 | P63316 | Troponin C, slow skeletal and cardiac muscles | other | targets |
| P08183 | ABCB1 | ATP-dependent translocase ABCB1 | inhibitor | transporters |