Molecule Details
InChIKeyUBQNRHZMVUUOMG-UHFFFAOYSA-N
Compound NameZonisamide
Canonical SMILESN=S(=O)(O)Cc1noc2ccccc12
Clinical Status Clinical Multi-Target
Targets (Human+Pathogen)14
Pfam Stratification Cross-Family
Avg pChEMBL7.2
SourceBindingDB;ChEMBL;TTD_MultiTarget
2D Structure
2D structure
Activity Profile
DrugBank Annotations
DrugBank ID DB00909
Drug NameZonisamide
CAS Number68291-97-4
Groups approved investigational
ATC Codes N03AX15 G01AE10
DescriptionZonisamide is a sulfonamide anticonvulsant used as an adjunctive therapy in adults with partial-onset seizures.[L42530,L42535] Zonisamide may act by blocking repetitive firing of voltage-gated sodium channels, leading to a reduction of T-type calcium channel currents or by binding allosterically to ...
Categories: Agents causing hyperkalemia Amides Anti-epileptic Agent Antiarrhythmic agents Anticonvulsants Bradycardia-Causing Agents Calcium Channel Blockers Calcium-Regulating Hormones and Agents Carbonic Anhydrase Inhibitors Cardiovascular Agents Central Nervous System Agents Central Nervous System Depressants Compounds used in a research, industrial, or household setting Cytochrome P-450 CYP2C19 Inhibitors Cytochrome P-450 CYP2C19 Inhibitors (weak) Cytochrome P-450 CYP2C19 Substrates Cytochrome P-450 CYP3A Substrates Cytochrome P-450 CYP3A4 Substrates Cytochrome P-450 CYP3A5 Substrates Cytochrome P-450 Enzyme Inhibitors Cytochrome P-450 Substrates Decreased Central Nervous System Disorganized Electrical Activity Diuretics Drugs that are Mainly Renally Excreted Isoxazoles Membrane Transport Modulators Monoamine Oxidase A Inhibitors for interaction with Monoamine Oxidase A substrates Nervous System P-glycoprotein inhibitors Potential QTc-Prolonging Agents QTc Prolonging Agents Sulfonamides Sulfones Sulfur Compounds UGT1A1 Substrates
Cross-references: BindingDB: 50028010 ChEBI: 10127 CHEMBL750 ChemSpider: 5532 C07504 D00538 PDB: ZON PharmGKB: PA451978 PubChem:5734 PubChem:46505278 RxCUI: 39998 Therapeutic Targets Database: DAP000500 Wikipedia: Zonisamide ZINC: ZINC000000004321
Target Activities (14)
Target Gene Organism Category Pfam pChEMBL Type Source
O43570 CA12 Homo sapiens Human PF00194 8.4 Ki ChEMBL;BindingDB
Q16790 CA9 Homo sapiens Human PF00194 8.3 Ki ChEMBL;BindingDB
P18505 GABRB1 Homo sapiens Human PF02931 PF02932 8.0 pIC50 TTD_MultiTarget
P35218 CA5A Homo sapiens Human PF00194 7.7 Ki ChEMBL;BindingDB
Q9Y2D0 CA5B Homo sapiens Human PF00194 7.7 Ki ChEMBL
P00918 CA2 Homo sapiens Human PF00194 7.5 Ki ChEMBL;BindingDB
P00915 CA1 Homo sapiens Human PF00194 7.2 Ki ChEMBL;BindingDB
P23280 CA6 Homo sapiens Human PF00194 7.0 Ki ChEMBL;BindingDB
P43166 CA7 Homo sapiens Human PF00194 6.9 Ki ChEMBL;BindingDB
Q8N1Q1 CA13 Homo sapiens Human PF00194 6.4 Ki ChEMBL;BindingDB
P53615 NCE103 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) Pathogen PF00484 7.0 Ki ChEMBL;BindingDB
O24855 cynT Helicobacter pylori (strain ATCC 700392 / 26695) Pathogen PF00484 6.7 Ki ChEMBL;BindingDB
P9WPJ9 mtcA2 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) Pathogen PF00484 6.1 Ki ChEMBL;BindingDB
Q3I4V7 CAN2 Cryptococcus neoformans Pathogen PF00484 6.0 Ki ChEMBL;BindingDB
DrugBank Target Actions (39)
Target Gene Target Name Action Type
P33261 CYP2C19 Cytochrome P450 2C19 inhibitor enzymes
P08684 CYP3A4 Cytochrome P450 3A4 substrate enzymes
P20815 CYP3A5 Cytochrome P450 3A5 substrate enzymes
P22309 UGT1A1 UDP-glucuronosyltransferase 1A1 substrate enzymes
P33261 CYP2C19 Cytochrome P450 2C19 substrate enzymes
Q06278 AOX1 Aldehyde oxidase substrate enzymes
P14867 GABRA1 GABA(A) Receptor Benzodiazepine Binding Site binder targets
O43497 CACNA1G Voltage-dependent T-type calcium channel subunit alpha-1G inhibitor targets
O43570 CA12 Carbonic anhydrase 12 inhibitor targets
O60939 SCN2B Sodium channel regulatory subunit beta-2 inhibitor targets
O75493 CA11 Carbonic anhydrase-related protein 11 inhibitor targets
O95180 CACNA1H Voltage-dependent T-type calcium channel subunit alpha-1H inhibitor targets
P00915 CA1 Carbonic anhydrase 1 inhibitor targets
P00918 CA2 Carbonic anhydrase 2 inhibitor targets
P07451 CA3 Carbonic anhydrase 3 inhibitor targets
P21397 MAOA Amine oxidase [flavin-containing] A inhibitor targets
P22748 CA4 Carbonic anhydrase 4 inhibitor targets
P23280 CA6 Carbonic anhydrase 6 inhibitor targets
P27338 MAOB Amine oxidase [flavin-containing] B inhibitor targets
P35218 CA5A Carbonic anhydrase 5A, mitochondrial inhibitor targets
P35219 P35219 Carbonic anhydrase-related protein inhibitor targets
P35498 SCN1A Sodium channel protein type 1 subunit alpha inhibitor targets
P35499 SCN4A Sodium channel protein type 4 subunit alpha inhibitor targets
P43166 CA7 Carbonic anhydrase 7 inhibitor targets
Q07699 SCN1B Sodium channel regulatory subunit beta-1 inhibitor targets
Q14524 SCN5A Sodium channel protein type 5 subunit alpha inhibitor targets
Q15858 SCN9A Sodium channel protein type 9 subunit alpha inhibitor targets
Q16790 CA9 Carbonic anhydrase 9 inhibitor targets
Q8IWT1 Q8IWT1 Sodium channel regulatory subunit beta-4 inhibitor targets
Q8N1Q1 CA13 Carbonic anhydrase 13 inhibitor targets
Q99250 SCN2A Sodium channel protein type 2 subunit alpha inhibitor targets
Q9NS85 Q9NS85 Carbonic anhydrase-related protein 10 inhibitor targets
Q9NY46 SCN3A Sodium channel protein type 3 subunit alpha inhibitor targets
Q9NY72 Q9NY72 Sodium channel regulatory subunit beta-3 inhibitor targets
Q9P0X4 CACNA1I Voltage-dependent T-type calcium channel subunit alpha-1I inhibitor targets
Q9UI33 SCN11A Sodium channel protein type 11 subunit alpha inhibitor targets
Q9ULX7 CA14 Carbonic anhydrase 14 inhibitor targets
Q9Y2D0 CA5B Carbonic anhydrase 5B, mitochondrial inhibitor targets
P08183 ABCB1 ATP-dependent translocase ABCB1 inhibitor transporters