Molecule Details
InChIKeyUBIIFKJMNRPNMT-CQSZACIVSA-N
Compound NamePQ-10
Canonical SMILESCOc1cc2ncnc(N3CC[C@@H](Oc4cnc5ccccc5n4)C3)c2cc1OC
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)3
Pfam Stratification Homologous
Avg pChEMBL7.01
SourceChEMBL;BindingDB
2D Structure
2D structure
Activity Profile
DrugBank Annotations
DrugBank ID DB08391
Drug NamePQ-10
CAS Number927691-21-2
Groups experimental
ATC Codes nan
Descriptionnan
Cross-references: BindingDB: 14768 CHEMBL219445 ChemSpider: 10129890 PDB: PFJ PubChem:11955614 PubChem:99444862 Wikipedia: Culver_PQ-10 ZINC: ZINC000014956507
Target Activities (3)
Target Gene Organism Category Pfam pChEMBL Type Source
Q9Y233 PDE10A Homo sapiens Human PF01590 PF00233 7.8 IC50 ChEMBL;BindingDB
Q14432 PDE3A Homo sapiens Human PF00233 6.7 Ki ChEMBL;BindingDB
Q13370 PDE3B Homo sapiens Human PF00233 6.6 Ki ChEMBL;BindingDB
DrugBank Target Actions (1)
Target Gene Target Name Action Type
Q9Y233 PDE10A cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A binder targets