N-[1-(3-methoxyphenyl)ethyl]-4-methyl-5-(3-methyl-2H-indazol-5-yl)thiophene-2-carboxamide

InChIKey	`UAQJVFADAYIBGC-UHFFFAOYSA-N`
Compound Name	N-[1-(3-methoxyphenyl)ethyl]-4-methyl-5-(3-methyl-2H-indazol-5-yl)thiophene-2-carboxamide
Canonical SMILES	`COc1cccc(C(C)NC(=O)c2cc(C)c(-c3ccc4[nH]nc(C)c4c3)s2)c1`
Clinical Status	Data-mined Candidate
Targets (Human+Pathogen)	23
Pfam Stratification	Homologous
Avg pChEMBL	6.92
Source	ChEMBL

2D Structure

Activity Profile

Target	Gene	Organism	Category	Pfam	pChEMBL	Type	Source
Q05655	PRKCD	Homo sapiens	Human	PF00130 PF21494 PF00069 PF00433	8.1	Ki	ChEMBL
Q16513	PKN2	Homo sapiens	Human	PF02185 PF00069 PF00433	7.8	Ki	ChEMBL
P49840	GSK3A	Homo sapiens	Human	PF00069	7.7	Ki	ChEMBL
Q13464	ROCK1	Homo sapiens	Human	PF25346 PF00069 PF08912	7.7	Ki	ChEMBL
Q5VT25	CDC42BPA	Homo sapiens	Human	PF00130 PF00780 PF08826 PF15796 PF25346 PF00069 PF00433	7.6	Ki	ChEMBL
Q9HAZ1	CLK4	Homo sapiens	Human	PF00069	7.5	Ki	ChEMBL
Q12851	MAP4K2	Homo sapiens	Human	PF00780 PF00069	7.4	Ki	ChEMBL
P24941	CDK2	Homo sapiens	Human	PF00069	7.3	Ki	ChEMBL
P49841	GSK3B	Homo sapiens	Human	PF00069	7.3	Ki	ChEMBL
Q9HBY8	SGK2	Homo sapiens	Human	PF00069 PF00433	7.3	Ki	ChEMBL
O95819	MAP4K4	Homo sapiens	Human	PF00780 PF00069	7.2	Ki	ChEMBL
P05129	PRKCG	Homo sapiens	Human	PF00130 PF00168 PF00069 PF00433	6.7	Ki	ChEMBL
Q96GD4	AURKB	Homo sapiens	Human	PF00069	6.7	Ki	ChEMBL
Q8N4C8	MINK1	Homo sapiens	Human	PF00780 PF00069	6.6	Ki	ChEMBL
Q9Y4K4	MAP4K5	Homo sapiens	Human	PF00780 PF00069	6.5	Ki	ChEMBL
P23443	RPS6KB1	Homo sapiens	Human	PF00069 PF00433	6.4	Ki	ChEMBL
Q9BZL6	PRKD2	Homo sapiens	Human	PF00130 PF00169 PF00069 PF25525	6.4	Ki	ChEMBL
P28482	MAPK1	Homo sapiens	Human	PF00069	6.3	Ki	ChEMBL
Q9P1W9	PIM2	Homo sapiens	Human	PF00069	6.3	Ki	ChEMBL
Q9H2G2	SLK	Homo sapiens	Human	PF00069 PF12474	6.2	Ki	ChEMBL
O94806	PRKD3	Homo sapiens	Human	PF00130 PF00169 PF00069 PF25525	6.1	Ki	ChEMBL
P06493	CDK1	Homo sapiens	Human	PF00069	6.1	Ki	ChEMBL
Q00535	CDK5	Homo sapiens	Human	PF00069	6.0	Ki	ChEMBL