(2R,3R)-3-[[6-(4-amino-7-propan-2-ylpyrrolo[2,3-d]pyrimidine-5-carbonyl)pyrazin-2-yl]amino]-2-(4-fluorophenyl)pyrrolidine-1-carbaldehyde

InChIKey	`TZOLUHQWLXJGBH-XMSQKQJNSA-N`
Compound Name	(2R,3R)-3-[[6-(4-amino-7-propan-2-ylpyrrolo[2,3-d]pyrimidine-5-carbonyl)pyrazin-2-yl]amino]-2-(4-fluorophenyl)pyrrolidine-1-carbaldehyde
Canonical SMILES	`CC(C)n1cc(C(=O)c2cncc(N[C@@H]3CCN(C=O)[C@@H]3c3ccc(F)cc3)n2)c2c(N)ncnc21`
Clinical Status	Clinical Multi-Target
Targets (Human+Pathogen)	7
Pfam Stratification	Cross-Family
Avg pChEMBL	6.86
Source	ChEMBL;BindingDB;TTD_MultiTarget

2D Structure

Activity Profile

Target	Gene	Organism	Category	Pfam	pChEMBL	Type	Source
O15530	PDPK1	Homo sapiens	Human	PF14593 PF00069	7.2	IC50	ChEMBL;BindingDB
Q9P0L2	MARK1	Homo sapiens	Human	PF02149 PF00069 PF00627	7.0	IC50	ChEMBL;BindingDB
O14965	AURKA	Homo sapiens	Human	PF00069	6.8	IC50	ChEMBL;BindingDB
P31749	AKT1	Homo sapiens	Human	PF00169 PF00069 PF00433	6.8	pIC50	TTD_MultiTarget
P42345	MTOR	Homo sapiens	Human	PF02259 PF02260 PF08771 PF23593 PF11865 PF00454	6.8	pIC50	TTD_MultiTarget
P49841	GSK3B	Homo sapiens	Human	PF00069	6.7	IC50	ChEMBL;BindingDB
P04629	NTRK1	Homo sapiens	Human	PF13855 PF16920 PF07714 PF18613	6.7	IC50	ChEMBL;BindingDB