Molecule Details
InChIKeyTZDIAPGMMCTLTB-UHFFFAOYSA-N
Compound Name5-fluoro-N-(2-fluoro-4-piperazin-1-ylphenyl)-4-(8-fluoro-4-propan-2-yl-2,3-dihydro-1,4-benzoxazin-6-yl)pyrimidin-2-amine
Canonical SMILESCC(C)N1CCOc2c(F)cc(-c3nc(Nc4ccc(N5CCNCC5)cc4F)ncc3F)cc21
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)3
Pfam Stratification Cross-Family
Avg pChEMBL7.64
SourceChEMBL;BindingDB
2D Structure
2D structure
Activity Profile
Target Activities (3)
Target Gene Organism Category Pfam pChEMBL Type Source
P11802 CDK4 Homo sapiens Human PF00069 8.2 IC50 ChEMBL;BindingDB
Q00534 CDK6 Homo sapiens Human PF00069 8.1 IC50 ChEMBL;BindingDB
P07333 CSF1R Homo sapiens Human PF00047 PF25305 PF07714 6.6 IC50 ChEMBL;BindingDB