InChIKey	TZBJGXHYKVUXJN-UHFFFAOYSA-N
Compound Name	Genistein
Canonical SMILES	O=c1c(-c2ccc(O)cc2)coc2cc(O)cc(O)c12
Clinical Status	Clinical Multi-Target
Targets (Human+Pathogen)	12
Pfam Stratification	Cross-Family
Avg pChEMBL	6.89
Source	ChEMBL;BindingDB;TTD_MultiTarget

DrugBank ID	DB01645
Drug Name	Genistein
CAS Number	446-72-0
Groups	investigational
ATC Codes	nan
Description	An isoflavonoid derived from soy products. It inhibits protein-tyrosine kinase and topoisomerase-II (DNA topoisomerases, type II) activity and is used as an antineoplastic and antitumor agent. Experimentally, it has been shown to induce G2 phase arrest in human and murine cell lines. Additionally, g...

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Categories: Anticarcinogenic Agents Antineoplastic Agents BCRP/ABCG2 Inhibitors Benzopyrans Chromones Compounds used in a research, industrial, or household setting Cytochrome P-450 CYP1A2 Inhibitors Cytochrome P-450 CYP1A2 Inhibitors (weak) Cytochrome P-450 CYP1A2 Substrates Cytochrome P-450 CYP2C8 Inhibitors Cytochrome P-450 CYP2C8 Inhibitors (moderate) Cytochrome P-450 CYP2C9 Inhibitors Cytochrome P-450 CYP2C9 Inhibitors (strength unknown) Cytochrome P-450 CYP3A Inducers Cytochrome P-450 CYP3A4 Inducers Cytochrome P-450 CYP3A4 Inducers (weak) Cytochrome P-450 Enzyme Inducers Cytochrome P-450 Enzyme Inhibitors Cytochrome P-450 Substrates Enzyme Inhibitors Estrogens, Non-Steroidal Flavonoids Heterocyclic Compounds, Fused-Ring Hormones Hormones, Hormone Substitutes, and Hormone Antagonists Isoflavones OATP1B1/SLCO1B1 Inhibitors Organic Anion Transporting Polypeptide 2B1 Inhibitors P-glycoprotein inhibitors Phytoestrogens Protective Agents Protein Kinase Inhibitors Pyrans Tyrosine Kinase Inhibitors

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Cross-references: BindingDB: 19459 ChEBI: 28088 CHEMBL44 ChemSpider: 4444448 Guide to Pharmacology: 2826 IUPHAR: 2826 C06563 PDB: GEN PharmGKB: PA165109660 PubChem:5280961 PubChem:46509060 RxCUI: 25696 Therapeutic Targets Database: DCL000330 Wikipedia: Genistein ZINC: ZINC000018825330