Molecule Details
| InChIKey | TYMRLRRVMHJFTF-UHFFFAOYSA-N |
|---|---|
| Compound Name | Mafenide |
| Canonical SMILES | NCc1ccc(S(N)(=O)=O)cc1 |
| Clinical Status | Clinical Multi-Target |
| Targets (Human+Pathogen) | 9 |
| Pfam Stratification | Cross-Family |
| Avg pChEMBL | 7.01 |
| Source | BindingDB;ChEMBL;TTD_MultiTarget |
2D Structure
Activity Profile
DrugBank Annotations
| DrugBank ID | DB06795 |
|---|---|
| Drug Name | Mafenide |
| CAS Number | 138-39-6 |
| Groups | approved vet_approved withdrawn |
| ATC Codes | G01AE10 D06BA03 |
| Description | Mafenide is a sulfonamide-type antimicrobial agent used to treat severe burns. It acts by reducing the bacterial population present in the burn tissue and promotes healing of deep burns.[L36773] In 1998, mafenide acetate was approved under the FDA’s accelerated approval regulations. In November 2022... |
Categories: Amides Anti-Bacterial Agents Anti-Infective Agents Anti-Infective Agents, Local Benzene Derivatives Benzenesulfonamides Dermatologicals Drugs that are Mainly Renally Excreted Enzyme Inhibitors Folic Acid Antagonists Genito Urinary System and Sex Hormones Gynecological Antiinfectives and Antiseptics Methemoglobinemia Associated Agents Sulfonamide Antibacterial Sulfonamides Sulfones Sulfur Compounds
Cross-references: BindingDB: 10860 ChEBI: 6633 CHEMBL419 ChemSpider: 3858 Drugs Product Database (DPD): 11904 C07106 D02351 PDB: 6LH PubChem:3998 PubChem:310264891 RxCUI: 6572 Wikipedia: Mafenide ZINC: ZINC000000001644
Target Activities (9)
| Target | Gene | Organism | Category | Pfam | pChEMBL | Type | Source |
|---|---|---|---|---|---|---|---|
| O43570 | CA12 | Homo sapiens | Human | PF00194 | 9.5 | Ki | ChEMBL;BindingDB |
| P43166 | CA7 | Homo sapiens | Human | PF00194 | 7.1 | Ki | ChEMBL;BindingDB |
| Q16790 | CA9 | Homo sapiens | Human | PF00194 | 7.0 | Ki | ChEMBL;BindingDB |
| P00915 | CA1 | Homo sapiens | Human | PF00194 | 6.8 | Ki | ChEMBL;BindingDB |
| P00918 | CA2 | Homo sapiens | Human | PF00194 | 6.8 | Ki | ChEMBL;BindingDB |
| P18505 | GABRB1 | Homo sapiens | Human | PF02931 PF02932 | 6.8 | pIC50 | TTD_MultiTarget |
| Q31FD6 | Hydrogenovibrio crunogenus (strain DSM 25203 / XCL-2) | Pathogen | PF00194 | 6.7 | Ki | ChEMBL;BindingDB | |
| P53615 | NCE103 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | Pathogen | PF00484 | 6.4 | Ki | ChEMBL;BindingDB |
| O24855 | cynT | Helicobacter pylori (strain ATCC 700392 / 26695) | Pathogen | PF00484 | 6.1 | Ki | ChEMBL;BindingDB |