Molecule Details
InChIKeyTVLFEDKEAOXRCZ-UHFFFAOYSA-N
Compound NameSyk-IN-I
Canonical SMILESCCc1c(-c2ccc(C(C)(C)O)cc2)[nH]c2nccnc12
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)22
Pfam Stratification Cross-Family
Avg pChEMBL6.54
SourceChEMBL
2D Structure
2D structure
Activity Profile
Target Activities (22)
Target Gene Organism Category Pfam pChEMBL Type Source
Q04771 ACVR1 Homo sapiens Human PF01064 PF07714 PF08515 7.4 Ki ChEMBL
O00444 PLK4 Homo sapiens Human PF00069 PF18190 PF18409 7.3 Ki ChEMBL
O15530 PDPK1 Homo sapiens Human PF14593 PF00069 6.9 Ki ChEMBL
P51617 IRAK1 Homo sapiens Human PF00531 PF00069 6.9 Ki ChEMBL
O00311 CDC7 Homo sapiens Human PF00069 6.7 Ki ChEMBL
Q08881 ITK Homo sapiens Human PF00779 PF00169 PF07714 PF00017 PF00018 6.7 Ki ChEMBL
P12931 SRC Homo sapiens Human PF07714 PF00017 PF00018 6.6 Ki ChEMBL
P24941 CDK2 Homo sapiens Human PF00069 6.6 Ki ChEMBL
P42685 FRK Homo sapiens Human PF07714 PF00017 PF00018 6.6 Ki ChEMBL
P07949 RET Homo sapiens Human PF00028 PF07714 PF17756 PF17812 PF17813 PF22540 6.5 Ki ChEMBL
Q07912 TNK2 Homo sapiens Human PF09027 PF11555 PF07714 PF22931 PF14604 6.5 Ki ChEMBL
Q12851 MAP4K2 Homo sapiens Human PF00780 PF00069 6.5 Ki ChEMBL
Q13882 PTK6 Homo sapiens Human PF07714 PF00017 PF00018 6.5 Ki ChEMBL
O95819 MAP4K4 Homo sapiens Human PF00780 PF00069 6.4 Ki ChEMBL
O96017 CHEK2 Homo sapiens Human PF00498 PF00069 6.4 Ki ChEMBL
P51451 BLK Homo sapiens Human PF07714 PF00017 PF00018 6.3 Ki ChEMBL
Q8N4C8 MINK1 Homo sapiens Human PF00780 PF00069 6.3 Ki ChEMBL
O60674 JAK2 Homo sapiens Human PF18379 PF18377 PF17887 PF07714 PF21990 6.2 Ki ChEMBL
P27448 MARK3 Homo sapiens Human PF02149 PF00069 PF00627 6.2 Ki ChEMBL
Q5S007 LRRK2 Homo sapiens Human PF23745 PF23744 PF23748 PF16095 PF25497 PF13855 PF00069 PF08477 6.2 Ki ChEMBL
O14965 AURKA Homo sapiens Human PF00069 6.1 Ki ChEMBL
P22607 FGFR3 Homo sapiens Human PF21165 PF07679 PF13927 PF07714 6.1 Ki ChEMBL