Molecule Details
| InChIKey | SZFPYBIJACMNJV-UHFFFAOYSA-N |
|---|---|
| Canonical SMILES | CCCCCCCCCCCCCCCCCCOP(=O)([O-])OC1CC[N+](C)(C)CC1 |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 2 |
| Pfam Stratification | Cross-Family |
| Avg pChEMBL | 7.02 |
| Source | ChEMBL;BindingDB |
2D Structure
Activity Profile
DrugBank Annotations
| DrugBank ID | DB06641 |
|---|---|
| Drug Name | Perifosine |
| CAS Number | 157716-52-4 |
| Groups | investigational |
| ATC Codes | nan |
| Description | Perifosine is a novel alkylphospholipid with antiproliferative properties attributed to protein kinase B inhibition. |
Categories: Amines Onium Compounds Quaternary Ammonium Compounds Trimethyl Ammonium Compounds
Cross-references: BindingDB: 50431630 ChEBI: 67272 CHEMBL372764 ChemSpider: 130628 Wikipedia: Perifosine
Target Activities (2)
DrugBank Target Actions (4)
| Target | Gene | Target Name | Action | Type |
|---|---|---|---|---|
| P17252 | PRKCA | Protein kinase C alpha type | binder | targets |
| P28482 | MAPK1 | Mitogen-activated protein kinase 1 | binder | targets |
| P31749 | AKT1 | RAC-alpha serine/threonine-protein kinase | binder | targets |
| P48736 | PIK3CG | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | modulator | targets |