Molecule Details
| InChIKey | SXWMIXPJPNCXQQ-UHFFFAOYSA-N |
|---|---|
| Compound Name | Denfivontinib |
| Canonical SMILES | CN1CCC(Nc2nc(Nc3ccc(Oc4ccccc4)cc3)c3c(=O)[nH]cc(Br)c3n2)CC1 |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 4 |
| Pfam Stratification | Cross-Family |
| Avg pChEMBL | 7.74 |
| Source | BindingDB;ChEMBL |
2D Structure
Activity Profile
DrugBank Annotations
| DrugBank ID | DB17159 |
|---|---|
| Drug Name | Denfivontinib |
| CAS Number | 1457983-28-6 |
| Groups | investigational |
| ATC Codes | nan |
| Description | nan |
Cross-references: CHEMBL4544478 ChemSpider: 32813334 ZINC: ZINC000095644293
Target Activities (4)
| Target | Gene | Organism | Category | Pfam | pChEMBL | Type | Source |
|---|---|---|---|---|---|---|---|
| P36888 | FLT3 | Homo sapiens | Human | PF00047 PF07714 | 9.3 | IC50 | ChEMBL |
| Q9HCE5 | METTL14 | Homo sapiens | Human | PF05063 | 8.1 | IC50 | BindingDB |
| P30530 | AXL | Homo sapiens | Human | PF00041 PF13927 PF07714 | 7.3 | IC50 | BindingDB |
| O60674 | JAK2 | Homo sapiens | Human | PF18379 PF18377 PF17887 PF07714 PF21990 | 6.3 | IC50 | BindingDB |