Molecule Details
InChIKeySVZUZSDHGKVQNU-UHFFFAOYSA-N
Compound NameN-(5-(2-chlorophenyl)-2,10-dihydrobenzo[e]pyrazolo[4,3-b][1,4]diazepin-7-yl)acetamide
Canonical SMILESCC(=O)Nc1ccc2c(c1)C(c1ccccc1Cl)=Nc1c[nH]nc1N2
Clinical Status Clinical Multi-Target
Targets (Human+Pathogen)11
Pfam Stratification Cross-Family
Avg pChEMBL6.83
SourceChEMBL;BindingDB;TTD_MultiTarget
2D Structure
2D structure
Activity Profile
Target Activities (11)
Target Gene Organism Category Pfam pChEMBL Type Source
P35968 KDR Homo sapiens Human PF07679 PF00047 PF13895 PF22971 PF07714 PF21339 PF17988 PF22854 7.5 IC50 ChEMBL;BindingDB
O96020 CCNE2 Homo sapiens Human PF02984 PF00134 7.4 IC50 ChEMBL
P24864 CCNE1 Homo sapiens Human PF02984 PF00134 7.4 IC50 ChEMBL
P24941 CDK2 Homo sapiens Human PF00069 7.4 pIC50 TTD_MultiTarget
P11802 CDK4 Homo sapiens Human PF00069 6.9 pIC50 TTD_MultiTarget
Q05397 PTK2 Homo sapiens Human PF21477 PF00373 PF18038 PF03623 PF07714 6.7 IC50 ChEMBL;BindingDB
P78396 CCNA1 Homo sapiens Human PF02984 PF00134 PF16500 6.7 IC50 ChEMBL
P06493 CDK1 Homo sapiens Human PF00069 6.5 pIC50 TTD_MultiTarget
P24385 CCND1 Homo sapiens Human PF02984 PF00134 6.5 IC50 ChEMBL
P00533 EGFR Homo sapiens Human PF00757 PF14843 PF07714 PF01030 PF21314 6.1 IC50 ChEMBL;BindingDB
P12931 SRC Homo sapiens Human PF07714 PF00017 PF00018 6.0 IC50 ChEMBL;BindingDB