InChIKey	SUJUHGSWHZTSEU-FYBSXPHGSA-N
Compound Name	Tipranavir
Canonical SMILES	CCC[C@@]1(CCc2ccccc2)CC(O)=C([C@H](CC)c2cccc(NS(=O)(=O)c3ccc(C(F)(F)F)cn3)c2)C(=O)O1
Clinical Status	Data-mined Candidate
Targets (Human+Pathogen)	2
Pfam Stratification	Homologous
Avg pChEMBL	9.31
Source	BindingDB;ChEMBL

DrugBank ID	DB00932
Drug Name	Tipranavir
CAS Number	174484-41-4
Groups	approved
ATC Codes	J05AE09
Description	Tipranavir is a sulfonamide-containing dyhydropyrone and a nonpeptidic protease inhibitor that targets the HIV protease. Tipranavir and ritonavir are coadministered to treat HIV.

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Categories: Amides Anti-HIV Agents Anti-Infective Agents Anti-Retroviral Agents Antiinfectives for Systemic Use Antiviral Agents Antivirals for Systemic Use BSEP/ABCB11 Inhibitors BSEP/ABCB11 Substrates Cytochrome P-450 CYP2C19 Inhibitors Cytochrome P-450 CYP2C19 Inhibitors (weak) Cytochrome P-450 CYP2C19 Substrates Cytochrome P-450 CYP2D6 Inhibitors Cytochrome P-450 CYP2D6 Inhibitors (moderate) Cytochrome P-450 CYP2D6 Substrates Cytochrome P-450 CYP3A Inhibitors Cytochrome P-450 CYP3A Substrates Cytochrome P-450 CYP3A4 Inhibitors Cytochrome P-450 CYP3A4 Inhibitors (strong) Cytochrome P-450 CYP3A4 Substrates Cytochrome P-450 Enzyme Inhibitors Cytochrome P-450 Substrates Direct Acting Antivirals Drugs causing inadvertant photosensitivity Enzyme Inhibitors HIV Protease Inhibitors Hepatotoxic Agents Hyperglycemia-Associated Agents OATP1B1/SLCO1B1 Inhibitors OATP1B3 inhibitors Organic Anion Transporting Polypeptide 2B1 Inhibitors P-glycoprotein inducers P-glycoprotein inhibitors P-glycoprotein substrates Photosensitizing Agents Protease Inhibitors Pyrans Sulfones Sulfur Compounds UGT1A1 Inducers

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Cross-references: BindingDB: 50479982 ChEBI: 63628 CHEMBL222559 ChemSpider: 10482313 Drugs Product Database (DPD): 12684 PDB: TPV PharmGKB: PA163522473 PubChem:54682461 PubChem:46506257 RxCUI: 190548 Therapeutic Targets Database: DAP001085 Wikipedia: Tipranavir ZINC: ZINC000100016058