Molecule Details
| InChIKey | STGJRXCRLCYESQ-UHFFFAOYSA-N |
|---|---|
| Compound Name | 2-[4-[2-(3-Chloroanilino)-4-(1,2,3,4-tetrahydroisoquinolin-7-ylamino)pyrimidin-5-yl]pyrazol-1-yl]ethanol |
| Canonical SMILES | OCCn1cc(-c2cnc(Nc3cccc(Cl)c3)nc2Nc2ccc3c(c2)CNCC3)cn1 |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 3 |
| Pfam Stratification | Homologous |
| Avg pChEMBL | 7.88 |
| Source | ChEMBL;BindingDB |
2D Structure
Activity Profile
Target Activities (3)
| Target | Gene | Organism | Category | Pfam | pChEMBL | Type | Source |
|---|---|---|---|---|---|---|---|
| Q06418 | TYRO3 | Homo sapiens | Human | PF00041 PF07679 PF07714 | 10.1 | IC50 | ChEMBL;BindingDB |
| Q12866 | MERTK | Homo sapiens | Human | PF00041 PF00047 PF13927 PF07714 | 7.4 | IC50 | ChEMBL;BindingDB |
| P30530 | AXL | Homo sapiens | Human | PF00041 PF13927 PF07714 | 6.1 | IC50 | ChEMBL;BindingDB |