N-(4-(benzo[d]thiazol-2-yl)-2-methylphenyl)-6-methoxy-7-(3-(4-methylpiperazin-1-yl)propoxy)quinazolin-4-amine

InChIKey	`SSHDKAJDJAVHAF-UHFFFAOYSA-N`
Compound Name	N-(4-(benzo[d]thiazol-2-yl)-2-methylphenyl)-6-methoxy-7-(3-(4-methylpiperazin-1-yl)propoxy)quinazolin-4-amine
Canonical SMILES	`COc1cc2c(Nc3ccc(-c4nc5ccccc5s4)cc3C)ncnc2cc1OCCCN1CCN(C)CC1`
Clinical Status	Clinical Multi-Target
Targets (Human+Pathogen)	8
Pfam Stratification	Cross-Family
Avg pChEMBL	6.62
Source	ChEMBL;BindingDB;TTD_MultiTarget

2D Structure

Activity Profile

Target	Gene	Organism	Category	Pfam	pChEMBL	Type	Source
Q02763	TEK	Homo sapiens	Human	PF00041 PF10430 PF07714	7.4	IC50	ChEMBL;BindingDB
P00533	EGFR	Homo sapiens	Human	PF00757 PF14843 PF07714 PF01030 PF21314	6.6	IC50	ChEMBL;BindingDB
P04626	ERBB2	Homo sapiens	Human	PF00757 PF14843 PF07714 PF01030 PF21314	6.6	pIC50	TTD_MultiTarget
P35968	KDR	Homo sapiens	Human	PF07679 PF00047 PF13895 PF22971 PF07714 PF21339 PF17988 PF22854	6.6	IC50	ChEMBL;BindingDB
O14965	AURKA	Homo sapiens	Human	PF00069	6.5	IC50	ChEMBL;BindingDB
O75716	STK16	Homo sapiens	Human	PF00069	6.5	pIC50	TTD_MultiTarget
P35916	FLT4	Homo sapiens	Human	PF07679 PF13927 PF22971 PF07714 PF21339 PF17988 PF22854	6.5	IC50	ChEMBL;BindingDB
Q96GD4	AURKB	Homo sapiens	Human	PF00069	6.4	IC50	ChEMBL;BindingDB