Molecule Details
| InChIKey | SONNWYBIRXJNDC-VIFPVBQESA-N |
|---|---|
| Compound Name | Phenylephrine |
| Canonical SMILES | CNC[C@H](O)c1cccc(O)c1 |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 3 |
| Pfam Stratification | Homologous |
| Avg pChEMBL | 6.41 |
| Source | ChEMBL;BindingDB |
2D Structure
Activity Profile
DrugBank Annotations
| DrugBank ID | DB00388 |
|---|---|
| Drug Name | Phenylephrine |
| CAS Number | 59-42-7 |
| Groups | approved investigational |
| ATC Codes | S01FB01 R01AB01 C01CA06 R01AA04 C05AX06 S01FB51 S01GA05 R01BA53 S01GA55 R01BA03 |
| Description | Phenylephrine is an alpha-1 adrenergic receptor agonist used to treat hypotension,[L9416,L9410] dilate the pupil,[L9413] and induce local vasoconstriction.[A187370] The action of phenylephrine, or neo-synephrine, was first described in literature in the 1930s.[A187376] Phenylephrine was granted FDA ... |
Categories: Adrenergic Agents Adrenergic Agonists Adrenergic alpha-1 Receptor Agonists Adrenergic alpha-Agonists Adrenergic and Dopaminergic Agents Agents for Treatment of Hemorrhoids and Anal Fissures for Topical Use Agents producing tachycardia Agents that produce hypertension Alcohols Amines Amino Alcohols Autonomic Agents Cardiac Stimulants Excl. Cardiac Glycosides Cardiac Therapy Cardiotonic Agents Cardiovascular Agents Compounds used in a research, industrial, or household setting Cytochrome P-450 CYP1A2 Inducers Cytochrome P-450 CYP1A2 Inducers (strength unknown) Cytochrome P-450 Enzyme Inducers Decongestants and Antiallergics Ethanolamines Monoamine Oxidase A Substrates Mydriatics Mydriatics and Cycloplegics Nasal Decongestants Nasal Decongestants for Systemic Use Nasal Preparations Neurotransmitter Agents Ophthalmologicals Peripheral Nervous System Agents Protective Agents Respiratory System Agents Sensory Organs Sympathomimetic (Adrenergic) Agents Sympathomimetics Sympathomimetics Excl. Antiglaucoma Preparations Sympathomimetics Used as Decongestants Sympathomimetics, Plain Vasoconstrictor Agents Vasoprotectives
Cross-references: BindingDB: 50067212 ChEBI: 8093 CHEMBL1215 ChemSpider: 5818 Drugs Product Database (DPD): 10258 Guide to Pharmacology: 485 IUPHAR: 485 C07441 D08365 PharmGKB: PA450935 PubChem:6041 PubChem:46506961 RxCUI: 8163 Therapeutic Targets Database: DAP000224 Wikipedia: Phenylephrine ZINC: ZINC000000113355
Target Activities (3)
DrugBank Target Actions (8)
| Target | Gene | Target Name | Action | Type |
|---|---|---|---|---|
| P05177 | CYP1A2 | Cytochrome P450 1A2 | inducer | enzymes |
| P0DMM9 | P0DMM9 | Sulfotransferase 1A3 | substrate | enzymes |
| P21397 | MAOA | Amine oxidase [flavin-containing] A | substrate | enzymes |
| P27338 | MAOB | Amine oxidase [flavin-containing] B | substrate | enzymes |
| P14416 | DRD2 | D(2) dopamine receptor | agonist | targets |
| P25100 | ADRA1D | Alpha-1D adrenergic receptor | agonist | targets |
| P35348 | ADRA1A | Alpha-1A adrenergic receptor | agonist | targets |
| P35368 | ADRA1B | Alpha-1B adrenergic receptor | agonist | targets |