Molecule Details
| InChIKey | SLVMESMUVMCQIY-UHFFFAOYSA-N |
|---|---|
| Compound Name | Mesoridazine |
| Canonical SMILES | CN1CCCCC1CCN1c2ccccc2Sc2ccc(S(C)=O)cc21 |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 14 |
| Pfam Stratification | Cross-Family |
| Avg pChEMBL | 7.55 |
| Source | BindingDB;ChEMBL |
2D Structure
Activity Profile
DrugBank Annotations
| DrugBank ID | DB00933 |
|---|---|
| Drug Name | Mesoridazine |
| CAS Number | 5588-33-0 |
| Groups | approved withdrawn |
| ATC Codes | N05AC03 |
| Description | A phenothiazine antipsychotic with effects similar to chlorpromazine. |
Categories: Antidepressive Agents Antipsychotic Agents Antipsychotic Agents (First Generation [Typical]) Central Nervous System Agents Central Nervous System Depressants Cytochrome P-450 CYP2D6 Substrates Cytochrome P-450 Substrates Dopamine Agents Dopamine Antagonists Dopamine D2 Receptor Antagonists Heterocyclic Compounds, Fused-Ring Moderate Risk QTc-Prolonging Agents Nervous System Neurotoxic agents Neurotransmitter Agents Phenothiazines Phenothiazines With Piperidine Structure Psycholeptics Psychotropic Drugs QTc Prolonging Agents Serotonin 5-HT2 Receptor Antagonists Serotonin 5-HT2A Receptor Antagonists Serotonin Agents Serotonin Receptor Antagonists Sulfur Compounds Tranquilizing Agents
Cross-references: BindingDB: 50131440 ChEBI: 6780 CHEMBL1088 ChemSpider: 3936 Drugs Product Database (DPD): 11278 C07143 D02671 PharmGKB: PA450386 PubChem:4078 PubChem:46506724 RxCUI: 6779 Therapeutic Targets Database: DAP000252 Wikipedia: Mesoridazine
Target Activities (14)
| Target | Gene | Organism | Category | Pfam | pChEMBL | Type | Source |
|---|---|---|---|---|---|---|---|
| P35367 | HRH1 | Homo sapiens | Human | PF00001 | 8.7 | Ki | BindingDB |
| P35348 | ADRA1A | Homo sapiens | Human | PF00001 | 8.7 | Ki | BindingDB |
| P35462 | DRD3 | Homo sapiens | Human | PF00001 | 8.6 | Ki | BindingDB |
| P21917 | DRD4 | Homo sapiens | Human | PF00001 | 8.0 | Ki | BindingDB |
| P11229 | CHRM1 | Homo sapiens | Human | PF00001 | 8.0 | Ki | BindingDB |
| P08173 | CHRM4 | Homo sapiens | Human | PF00001 | 7.7 | Ki | BindingDB |
| P14416 | DRD2 | Homo sapiens | Human | PF00001 | 7.7 | Ki | BindingDB |
| P28335 | HTR2C | Homo sapiens | Human | PF00001 | 7.6 | Ki | BindingDB |
| P08912 | CHRM5 | Homo sapiens | Human | PF00001 | 7.2 | Ki | BindingDB |
| P08172 | CHRM2 | Homo sapiens | Human | PF00001 | 7.2 | Ki | BindingDB |
| P20309 | CHRM3 | Homo sapiens | Human | PF00001 | 7.0 | Ki | BindingDB |
| Q12809 | KCNH2 | Homo sapiens | Human | PF00027 PF00520 PF13426 | 6.5 | IC50 | ChEMBL;BindingDB |
| P50406 | HTR6 | Homo sapiens | Human | PF00001 | 6.4 | Ki | BindingDB |
| P08908 | HTR1A | Homo sapiens | Human | PF00001 | 6.3 | Ki | BindingDB |