Molecule Details
InChIKeySLVDFWRJWQJSRW-UHFFFAOYSA-N
Compound NamePI3K/mTOR Inhibitor-12
Canonical SMILESCOc1ncc(-c2ccc3ncc(-c4cn(CCCN5CCOCC5)nn4)n3n2)cc1NS(=O)(=O)c1ccc(F)cc1F
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)5
Pfam Stratification Homologous
Avg pChEMBL9.26
SourceChEMBL
2D Structure
2D structure
Activity Profile
Target Activities (5)
Target Gene Organism Category Pfam pChEMBL Type Source
P42336 PIK3CA Homo sapiens Human PF00454 PF00792 PF02192 PF00794 PF00613 10.2 IC50 ChEMBL
O00329 PIK3CD Homo sapiens Human PF00454 PF00792 PF02192 PF00794 PF00613 9.5 IC50 ChEMBL
P48736 PIK3CG Homo sapiens Human PF00454 PF00792 PF00794 PF00613 PF19710 9.1 IC50 ChEMBL
P42338 PIK3CB Homo sapiens Human PF00454 PF00792 PF02192 PF00794 PF00613 8.9 IC50 ChEMBL
P42345 MTOR Homo sapiens Human PF02259 PF02260 PF08771 PF23593 PF11865 PF00454 8.5 IC50 ChEMBL