Molecule Details
InChIKeySKVXOYIMICHFPV-UHFFFAOYSA-N
Compound Name8-(3-Phenoxy-benzyl)-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one
Canonical SMILESO=C1NCN(c2ccccc2)C12CCN(Cc1cccc(Oc3ccccc3)c1)CC2
Clinical Status Clinical Multi-Target
Targets (Human+Pathogen)10
Pfam Stratification Cross-Family
Avg pChEMBL6.48
SourceChEMBL;BindingDB;TTD_MultiTarget
2D Structure
2D structure
Activity Profile
Target Activities (10)
Target Gene Organism Category Pfam pChEMBL Type Source
P35372 OPRM1 Homo sapiens Human PF00001 7.1 IC50 ChEMBL;BindingDB
P41145 OPRK1 Homo sapiens Human PF00001 7.0 IC50 ChEMBL;BindingDB
P35462 DRD3 Homo sapiens Human PF00001 6.8 IC50 ChEMBL;BindingDB
P35348 ADRA1A Homo sapiens Human PF00001 6.3 pIC50 TTD_MultiTarget
P35367 HRH1 Homo sapiens Human PF00001 6.3 IC50 ChEMBL;BindingDB
P14416 DRD2 Homo sapiens Human PF00001 6.3 IC50 ChEMBL;BindingDB
O60840 CACNA1F Homo sapiens Human PF08763 PF16885 PF16905 PF00520 6.3 IC50 ChEMBL
Q01668 CACNA1D Homo sapiens Human PF08763 PF16885 PF16905 PF00520 6.3 IC50 ChEMBL
Q13698 CACNA1S Homo sapiens Human PF08763 PF16905 PF00520 6.3 IC50 ChEMBL
Q13936 CACNA1C Homo sapiens Human PF08763 PF16885 PF16905 PF00520 6.3 IC50 ChEMBL;BindingDB