2,4,4-trimethyl-N-(5-piperazin-1-yl-2-pyridinyl)-3-propan-2-yl-5H-imidazo[4,5-h]quinazolin-8-amine

InChIKey	`SKIRJBWKEIJSMN-UHFFFAOYSA-N`
Compound Name	2,4,4-trimethyl-N-(5-piperazin-1-yl-2-pyridinyl)-3-propan-2-yl-5H-imidazo[4,5-h]quinazolin-8-amine
Canonical SMILES	`Cc1nc2c(n1C(C)C)C(C)(C)Cc1cnc(Nc3ccc(N4CCNCC4)cn3)nc1-2`
Clinical Status	Data-mined Candidate
Targets (Human+Pathogen)	3
Pfam Stratification	Cross-Family
Avg pChEMBL	7.26
Source	BindingDB;ChEMBL

2D Structure

Activity Profile

Target	Gene	Organism	Category	Pfam	pChEMBL	Type	Source
P11802	CDK4	Homo sapiens	Human	PF00069	8.0	IC50	ChEMBL;BindingDB
P24385	CCND1	Homo sapiens	Human	PF02984 PF00134	7.7	IC50	ChEMBL;BindingDB
P24941	CDK2	Homo sapiens	Human	PF00069	6.1	IC50	BindingDB