1-[4-[4-Amino-3-[4-(2-morpholin-4-ylethoxy)phenyl]pyrazolo[3,4-d]pyrimidin-1-yl]phenyl]-3-(5-tert-butyl-1,2-oxazol-3-yl)urea

InChIKey	`SKDBXDGKLQALIZ-UHFFFAOYSA-N`
Compound Name	1-[4-[4-Amino-3-[4-(2-morpholin-4-ylethoxy)phenyl]pyrazolo[3,4-d]pyrimidin-1-yl]phenyl]-3-(5-tert-butyl-1,2-oxazol-3-yl)urea
Canonical SMILES	`CC(C)(C)c1cc(NC(=O)Nc2ccc(-n3nc(-c4ccc(OCCN5CCOCC5)cc4)c4c(N)ncnc43)cc2)no1`
Clinical Status	Data-mined Candidate
Targets (Human+Pathogen)	15
Pfam Stratification	Cross-Family
Avg pChEMBL	7.0
Source	ChEMBL;BindingDB

2D Structure

Activity Profile

Target	Gene	Organism	Category	Pfam	pChEMBL	Type	Source
P07949	RET	Homo sapiens	Human	PF00028 PF07714 PF17756 PF17812 PF17813 PF22540	7.5	IC50	ChEMBL;BindingDB
P21127	CDK11B	Homo sapiens	Human	PF00069	7.4	IC50	ChEMBL;BindingDB
P24863	CCNC	Homo sapiens	Human	PF16899 PF00134	7.3	IC50	ChEMBL
P49336	CDK8	Homo sapiens	Human	PF00069	7.3	IC50	ChEMBL;BindingDB
Q16832	DDR2	Homo sapiens	Human	PF21114 PF00754 PF07714	7.2	IC50	ChEMBL;BindingDB
Q9HBH9	MKNK2	Homo sapiens	Human	PF00069	7.2	IC50	ChEMBL;BindingDB
Q08345	DDR1	Homo sapiens	Human	PF21114 PF00754 PF07714	7.2	IC50	ChEMBL;BindingDB
P10721	KIT	Homo sapiens	Human	PF00047 PF07714	7.1	IC50	ChEMBL;BindingDB
P36888	FLT3	Homo sapiens	Human	PF00047 PF07714	7.0	IC50	ChEMBL;BindingDB
Q06187	BTK	Homo sapiens	Human	PF00779 PF00169 PF07714 PF00017 PF00018	7.0	IC50	ChEMBL;BindingDB
P35916	FLT4	Homo sapiens	Human	PF07679 PF13927 PF22971 PF07714 PF21339 PF17988 PF22854	6.8	IC50	ChEMBL;BindingDB
P07333	CSF1R	Homo sapiens	Human	PF00047 PF25305 PF07714	6.8	IC50	ChEMBL;BindingDB
P06239	LCK	Homo sapiens	Human	PF07714 PF00017 PF00018	6.4	IC50	ChEMBL;BindingDB
P16234	PDGFRA	Homo sapiens	Human	PF07679 PF25305 PF07714	6.4	IC50	ChEMBL;BindingDB
P09619	PDGFRB	Homo sapiens	Human	PF00047 PF13927 PF25305 PF07714	6.2	IC50	ChEMBL;BindingDB