Molecule Details
| InChIKey | SGUZXWKWTMWMCR-LBPRGKRZSA-N |
|---|---|
| Compound Name | 4-N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-N-[(1S)-1-(1H-indol-5-yl)ethyl]pyrimidine-2,4-diamine |
| Canonical SMILES | C[C@H](Nc1nccc(Nc2cc(C3CC3)[nH]n2)n1)c1ccc2[nH]ccc2c1 |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 4 |
| Pfam Stratification | Homologous |
| Avg pChEMBL | 7.18 |
| Source | ChEMBL;BindingDB |
2D Structure
Activity Profile
Target Activities (4)
| Target | Gene | Organism | Category | Pfam | pChEMBL | Type | Source |
|---|---|---|---|---|---|---|---|
| Q13153 | PAK1 | Homo sapiens | Human | PF00786 PF00069 | 7.5 | Ki | ChEMBL;BindingDB |
| O96013 | PAK4 | Homo sapiens | Human | PF00786 PF00069 | 7.4 | Ki | ChEMBL;BindingDB |
| O75914 | PAK3 | Homo sapiens | Human | PF00786 PF00069 | 6.9 | IC50 | ChEMBL |
| Q13177 | PAK2 | Homo sapiens | Human | PF00786 PF00069 | 6.9 | IC50 | ChEMBL |