InChIKey	SGTNSNPWRIOYBX-UHFFFAOYSA-N
Compound Name	Verapamil
Canonical SMILES	COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC
Clinical Status	Data-mined Candidate
Targets (Human+Pathogen)	19
Pfam Stratification	Cross-Family
Avg pChEMBL	6.64
Source	ChEMBL;BindingDB

DrugBank ID	DB00661
Drug Name	Verapamil
CAS Number	52-53-9
Groups	approved investigational
ATC Codes	C09BB10 C08DA51 C08DA01
Description	Verapamil is a phenylalkylamine calcium channel blocker used in the treatment of high blood pressure, heart arrhythmias, and angina,[L8791] and was the first calcium channel antagonist to be introduced into therapy in the early 1960s.[A188514] It is a member of the non-dihydropyridine class of calci...

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Categories: ACE Inhibitors and Calcium Channel Blockers Adrenergic Antagonists Adrenergic alpha-1 Receptor Antagonists Adrenergic alpha-Antagonists Amines Antiarrhythmic agents Antihypertensive Agents Antihypertensive Agents Indicated for Hypertension Bradycardia-Causing Agents Calcium Channel Blockers Calcium Channel Blockers (Nondihydropyridine) Cardiovascular Agents Cytochrome P-450 CYP1A2 Substrates Cytochrome P-450 CYP2B6 Substrates Cytochrome P-450 CYP2C18 Substrates Cytochrome P-450 CYP2C19 Substrates Cytochrome P-450 CYP2C8 Inhibitors Cytochrome P-450 CYP2C8 Inhibitors (strength unknown) Cytochrome P-450 CYP2C8 Substrates Cytochrome P-450 CYP2C9 Inhibitors Cytochrome P-450 CYP2C9 Inhibitors (weak) Cytochrome P-450 CYP2C9 Substrates Cytochrome P-450 CYP2D6 Inhibitors Cytochrome P-450 CYP2D6 Inhibitors (strength unknown) Cytochrome P-450 CYP2D6 Inhibitors (weak) Cytochrome P-450 CYP2E1 Substrates Cytochrome P-450 CYP3A Inhibitors Cytochrome P-450 CYP3A Substrates Cytochrome P-450 CYP3A4 Inhibitors Cytochrome P-450 CYP3A4 Inhibitors (moderate) Cytochrome P-450 CYP3A4 Substrates Cytochrome P-450 CYP3A5 Inhibitors Cytochrome P-450 CYP3A5 Inhibitors (moderate) Cytochrome P-450 CYP3A5 Substrates Cytochrome P-450 Enzyme Inhibitors Cytochrome P-450 Substrates Drugs that are Mainly Renally Excreted Hypotensive Agents MATE 1 Inhibitors MATE 2 Inhibitors MATE inhibitors Membrane Transport Modulators Miscellaneous Calcium-channel Blocking Agents Negative Inotrope OATP1B1/SLCO1B1 Inhibitors OCT1 inhibitors OCT1 substrates P-glycoprotein inhibitors P-glycoprotein substrates Phenylalkylamine Derivatives Selective Calcium Channel Blockers With Direct Cardiac Effects Vasodilating Agents Verapamil and analogues

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Cross-references: BindingDB: 81939 ChEBI: 77733 CHEMBL6966 ChemSpider: 2425 Drugs Product Database (DPD): 10110 Guide to Pharmacology: 2406 IUPHAR: 2406 C07188 D02356 PharmGKB: PA451868 PubChem:2520 PubChem:46508158 RxCUI: 11170 Therapeutic Targets Database: DAP000040 Wikipedia: Verapamil