Molecule Details
InChIKeySGHXFHRRWFLILP-XJDXJNMNSA-N
Compound Name(1S)-2-(1H-Indol-3-YL)-1-[({5-[(E)-2-pyridin-4-ylvinyl]pyridin-3-YL}oxy)methyl]ethylamine
Canonical SMILESN[C@H](COc1cncc(/C=C/c2ccncc2)c1)Cc1c[nH]c2ccccc12
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)8
Pfam Stratification Homologous
Avg pChEMBL6.9
SourceBindingDB;ChEMBL
2D Structure
2D structure
Activity Profile
DrugBank Annotations
DrugBank ID DB07107
Drug Name(1S)-2-(1H-INDOL-3-YL)-1-[({5-[(E)-2-PYRIDIN-4-YLVINYL]PYRIDIN-3-YL}OXY)METHYL]ETHYLAMINE
CAS Numbernan
Groups experimental
ATC Codes nan
Descriptionnan

Cross-references: BindingDB: 15022 CHEMBL383541 ChemSpider: 5290493 PDB: 4EA PubChem:6914613 PubChem:99443578 ZINC: ZINC000014957382
Target Activities (8)
Target Gene Organism Category Pfam pChEMBL Type Source
P31749 AKT1 Homo sapiens Human PF00169 PF00069 PF00433 7.8 IC50 ChEMBL;BindingDB
P17612 PRKACA Homo sapiens Human PF00069 7.4 IC50 ChEMBL
P22612 PRKACG Homo sapiens Human PF00069 7.4 IC50 ChEMBL
P22694 PRKACB Homo sapiens Human PF00069 7.4 IC50 ChEMBL
P31751 AKT2 Homo sapiens Human PF00169 PF00069 PF00433 6.6 IC50 ChEMBL;BindingDB
Q9Y243 AKT3 Homo sapiens Human PF00169 PF00069 PF00433 6.5 IC50 ChEMBL;BindingDB
Q05513 PRKCZ Homo sapiens Human PF00130 PF00564 PF00069 PF00433 6.0 IC50 BindingDB
Q05655 PRKCD Homo sapiens Human PF00130 PF21494 PF00069 PF00433 6.0 IC50 ChEMBL
DrugBank Target Actions (2)
Target Gene Target Name Action Type
P17612 PRKACA cAMP-dependent protein kinase catalytic subunit alpha binder targets
P61925 P61925 cAMP-dependent protein kinase inhibitor alpha binder targets