Molecule Details
InChIKeySGHXFHRRWFLILP-UHFFFAOYSA-N
Compound Name1-(1H-indol-3-yl)-3-[[5-(2-pyridin-4-ylethenyl)-3-pyridinyl]oxy]propan-2-amine
Canonical SMILESNC(COc1cncc(C=Cc2ccncc2)c1)Cc1c[nH]c2ccccc12
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)29
Pfam Stratification Homologous
Avg pChEMBL6.81
SourceChEMBL
2D Structure
2D structure
Activity Profile
Target Activities (29)
Target Gene Organism Category Pfam pChEMBL Type Source
Q9HAZ1 CLK4 Homo sapiens Human PF00069 8.5 Ki ChEMBL
O75116 ROCK2 Homo sapiens Human PF25346 PF00069 PF08912 7.8 Ki ChEMBL
P31749 AKT1 Homo sapiens Human PF00169 PF00069 PF00433 7.7 Ki ChEMBL
Q16513 PKN2 Homo sapiens Human PF02185 PF00069 PF00433 7.7 Ki ChEMBL
P49760 CLK2 Homo sapiens Human PF00069 7.6 Ki ChEMBL
P51817 PRKX Homo sapiens Human PF00069 7.6 Ki ChEMBL
Q13464 ROCK1 Homo sapiens Human PF25346 PF00069 PF08912 7.6 Ki ChEMBL
P17612 PRKACA Homo sapiens Human PF00069 7.5 Ki ChEMBL
Q13976 PRKG1 Homo sapiens Human PF00027 PF16808 PF00069 7.5 Ki ChEMBL
Q13627 DYRK1A Homo sapiens Human PF00069 7.4 Ki ChEMBL
Q13237 PRKG2 Homo sapiens Human PF00027 PF00069 7.0 Ki ChEMBL
P31751 AKT2 Homo sapiens Human PF00169 PF00069 PF00433 6.9 Ki ChEMBL
O75582 RPS6KA5 Homo sapiens Human PF00069 PF00433 6.8 Ki ChEMBL
O00311 CDC7 Homo sapiens Human PF00069 6.4 Ki ChEMBL
O43781 DYRK3 Homo sapiens Human PF00069 6.4 Ki ChEMBL
O95819 MAP4K4 Homo sapiens Human PF00780 PF00069 6.4 Ki ChEMBL
P11309 PIM1 Homo sapiens Human PF00069 6.4 Ki ChEMBL
P49840 GSK3A Homo sapiens Human PF00069 6.4 Ki ChEMBL
Q9UEE5 STK17A Homo sapiens Human PF00069 6.4 Ki ChEMBL
Q9Y243 AKT3 Homo sapiens Human PF00169 PF00069 PF00433 6.4 Ki ChEMBL
Q96KB5 PBK Homo sapiens Human PF00069 6.3 Ki ChEMBL
O15111 CHUK Homo sapiens Human PF18397 PF12179 PF00069 6.2 Ki ChEMBL
P23443 RPS6KB1 Homo sapiens Human PF00069 PF00433 6.2 Ki ChEMBL
Q05655 PRKCD Homo sapiens Human PF00130 PF21494 PF00069 PF00433 6.2 Ki ChEMBL
O94806 PRKD3 Homo sapiens Human PF00130 PF00169 PF00069 PF25525 6.1 Ki ChEMBL
P51812 RPS6KA3 Homo sapiens Human PF00069 PF00433 6.1 Ki ChEMBL
P05129 PRKCG Homo sapiens Human PF00130 PF00168 PF00069 PF00433 6.0 Ki ChEMBL
Q86V86 PIM3 Homo sapiens Human PF00069 6.0 Ki ChEMBL
Q9P1W9 PIM2 Homo sapiens Human PF00069 6.0 Ki ChEMBL