Molecule Details
InChIKeySEZFNTZQMWJIAI-FLIBITNWSA-N
Compound Name(Z)-3-((1H-pyrrol-2-yl)methylene)indolin-2-one
Canonical SMILESO=C1Nc2ccccc2/C1=C/c1ccc[nH]1
Clinical Status Clinical Multi-Target
Targets (Human+Pathogen)9
Pfam Stratification Cross-Family
Avg pChEMBL6.45
SourceChEMBL;BindingDB;TTD_MultiTarget
2D Structure
2D structure
Activity Profile
Target Activities (9)
Target Gene Organism Category Pfam pChEMBL Type Source
P35968 KDR Homo sapiens Human PF07679 PF00047 PF13895 PF22971 PF07714 PF21339 PF17988 PF22854 6.8 IC50 ChEMBL;BindingDB
Q02161 RHD Homo sapiens Human PF00909 6.8 pIC50 TTD_MultiTarget
P36888 FLT3 Homo sapiens Human PF00047 PF07714 6.5 IC50 ChEMBL;BindingDB
O94768 STK17B Homo sapiens Human PF00069 6.5 Kd ChEMBL;BindingDB
Q96SB4 SRPK1 Homo sapiens Human PF00069 6.4 Kd ChEMBL;BindingDB
P07949 RET Homo sapiens Human PF00028 PF07714 PF17756 PF17812 PF17813 PF22540 6.3 IC50 ChEMBL;BindingDB
Q86UE8 TLK2 Homo sapiens Human PF00069 6.3 IC50 ChEMBL
O15530 PDPK1 Homo sapiens Human PF14593 PF00069 6.3 IC50 ChEMBL
P52333 JAK3 Homo sapiens Human PF18379 PF18377 PF17887 PF07714 PF21990 6.0 IC50 ChEMBL;BindingDB