Molecule Details
| InChIKey | SEJGTFPOEJWEGG-UHFFFAOYSA-N |
|---|---|
| Compound Name | 1-N-(4-fluorocyclohexa-1,5-dien-1-yl)-1-N'-[3-fluoro-4-[6-methoxy-7-(3-morpholin-4-ylpropoxy)quinolin-4-yl]oxyphenyl]cyclopropane-1,1-dicarboxamide |
| Canonical SMILES | COc1cc2c(Oc3ccc(NC(=O)C4(C(=O)NC5=CCC(F)C=C5)CC4)cc3F)ccnc2cc1OCCCN1CCOCC1 |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 149 |
| Pfam Stratification | Cross-Family |
| Avg pChEMBL | 7.37 |
| Source | BindingDB |
2D Structure
Activity Profile
Target Activities (149)
| Target | Gene | Organism | Category | Pfam | pChEMBL | Type | Source |
|---|---|---|---|---|---|---|---|
| P30530 | AXL | Homo sapiens | Human | PF00041 PF13927 PF07714 | 10.0 | Kd | BindingDB |
| Q08345 | DDR1 | Homo sapiens | Human | PF21114 PF00754 PF07714 | 9.7 | Kd | BindingDB |
| Q12866 | MERTK | Homo sapiens | Human | PF00041 PF00047 PF13927 PF07714 | 9.6 | Kd | BindingDB |
| Q8NE63 | HIPK4 | Homo sapiens | Human | PF00069 | 9.3 | Kd | BindingDB |
| O94804 | STK10 | Homo sapiens | Human | PF00069 PF12474 | 9.3 | Kd | BindingDB |
| P35590 | TIE1 | Homo sapiens | Human | PF00041 PF00047 PF07714 | 9.1 | Kd | BindingDB |
| P09619 | PDGFRB | Homo sapiens | Human | PF00047 PF13927 PF25305 PF07714 | 9.0 | Kd | BindingDB |
| P08581 | MET | Homo sapiens | Human | PF07714 PF01437 PF01403 PF01833 | 9.0 | Kd | BindingDB |
| P29320 | EPHA3 | Homo sapiens | Human | PF14575 PF25599 PF01404 PF07699 PF00041 PF07714 PF07647 | 9.0 | Kd | BindingDB |
| P07949 | RET | Homo sapiens | Human | PF00028 PF07714 PF17756 PF17812 PF17813 PF22540 | 9.0 | Kd | BindingDB |
| O15197 | EPHB6 | Homo sapiens | Human | PF14575 PF25599 PF01404 PF07699 PF00041 PF07714 PF07647 | 8.9 | Kd | BindingDB |
| P35916 | FLT4 | Homo sapiens | Human | PF07679 PF13927 PF22971 PF07714 PF21339 PF17988 PF22854 | 8.8 | Kd | BindingDB |
| P36888 | FLT3 | Homo sapiens | Human | PF00047 PF07714 | 8.8 | Kd | BindingDB |
| Q9UF33 | EPHA6 | Homo sapiens | Human | PF14575 PF25599 PF01404 PF07699 PF00041 PF07714 PF00536 | 8.8 | Kd | BindingDB |
| P07333 | CSF1R | Homo sapiens | Human | PF00047 PF25305 PF07714 | 8.7 | Kd | BindingDB |
| P29322 | EPHA8 | Homo sapiens | Human | PF14575 PF25599 PF01404 PF00041 PF07714 PF00536 | 8.7 | Kd | BindingDB |
| P54764 | EPHA4 | Homo sapiens | Human | PF14575 PF25599 PF01404 PF00041 PF07714 PF07647 | 8.7 | Kd | BindingDB |
| Q06418 | TYRO3 | Homo sapiens | Human | PF00041 PF07679 PF07714 | 8.7 | Kd | BindingDB |
| Q13163 | MAP2K5 | Homo sapiens | Human | PF00564 PF00069 | 8.6 | Kd | BindingDB |
| P10721 | KIT | Homo sapiens | Human | PF00047 PF07714 | 8.5 | Kd | BindingDB |
| Q04912 | MST1R | Homo sapiens | Human | PF07714 PF01437 PF01403 PF01833 | 8.5 | Kd | BindingDB |
| Q9H2G2 | SLK | Homo sapiens | Human | PF00069 PF12474 | 8.5 | Kd | BindingDB |
| Q02763 | TEK | Homo sapiens | Human | PF00041 PF10430 PF07714 | 8.5 | Kd | BindingDB |
| Q16288 | NTRK3 | Homo sapiens | Human | PF07679 PF00047 PF13855 PF16920 PF01462 PF07714 | 8.5 | Kd | BindingDB |
| O00444 | PLK4 | Homo sapiens | Human | PF00069 PF18190 PF18409 | 8.5 | Kd | BindingDB |
| P29317 | EPHA2 | Homo sapiens | Human | PF14575 PF25599 PF01404 PF00041 PF07714 PF00536 | 8.4 | Kd | BindingDB |
| Q16832 | DDR2 | Homo sapiens | Human | PF21114 PF00754 PF07714 | 8.4 | Kd | BindingDB |
| P50613 | CDK7 | Homo sapiens | Human | PF00069 | 8.4 | Kd | BindingDB |
| Q9HBH9 | MKNK2 | Homo sapiens | Human | PF00069 | 8.4 | Kd | BindingDB |
| P17948 | FLT1 | Homo sapiens | Human | PF07679 PF00047 PF13927 PF22971 PF07714 PF21339 PF17988 PF22854 | 8.4 | Kd | BindingDB |
| P42685 | FRK | Homo sapiens | Human | PF07714 PF00017 PF00018 | 8.4 | Kd | BindingDB |
| P29323 | EPHB2 | Homo sapiens | Human | PF14575 PF25599 PF01404 PF07699 PF00041 PF07714 PF00536 | 8.4 | Kd | BindingDB |
| Q9Y4K4 | MAP4K5 | Homo sapiens | Human | PF00780 PF00069 | 8.4 | Kd | BindingDB |
| Q16620 | NTRK2 | Homo sapiens | Human | PF07679 PF13855 PF16920 PF01462 PF07714 | 8.4 | Kd | BindingDB |
| Q13882 | PTK6 | Homo sapiens | Human | PF07714 PF00017 PF00018 | 8.4 | Kd | BindingDB |
| P16234 | PDGFRA | Homo sapiens | Human | PF07679 PF25305 PF07714 | 8.3 | Kd | BindingDB |
| P04629 | NTRK1 | Homo sapiens | Human | PF13855 PF16920 PF07714 PF18613 | 8.3 | Kd | BindingDB |
| P51451 | BLK | Homo sapiens | Human | PF07714 PF00017 PF00018 | 8.3 | Kd | BindingDB |
| Q56UN5 | MAP3K19 | Homo sapiens | Human | PF00069 | 8.3 | Kd | BindingDB |
| P06239 | LCK | Homo sapiens | Human | PF07714 PF00017 PF00018 | 8.2 | Kd | BindingDB |
| P21709 | EPHA1 | Homo sapiens | Human | PF14575 PF25599 PF01404 PF07699 PF00041 PF07714 PF00536 | 8.2 | Kd | BindingDB |
| P54756 | EPHA5 | Homo sapiens | Human | PF14575 PF25599 PF01404 PF00041 PF07714 PF00536 | 8.2 | Kd | BindingDB |
| P07948 | LYN | Homo sapiens | Human | PF07714 PF00017 PF00018 | 8.0 | Kd | BindingDB |
| P35968 | KDR | Homo sapiens | Human | PF07679 PF00047 PF13895 PF22971 PF07714 PF21339 PF17988 PF22854 | 7.9 | Kd | BindingDB |
| P54760 | EPHB4 | Homo sapiens | Human | PF14575 PF25599 PF01404 PF07699 PF00041 PF07714 PF00536 | 7.9 | Kd | BindingDB |
| P54762 | EPHB1 | Homo sapiens | Human | PF14575 PF25599 PF01404 PF00041 PF07714 PF00536 | 7.9 | Kd | BindingDB |
| Q02750 | MAP2K1 | Homo sapiens | Human | PF00069 | 7.9 | Kd | BindingDB |
| Q9UQB9 | AURKC | Homo sapiens | Human | PF00069 | 7.9 | Kd | BindingDB |
| O15146 | MUSK | Homo sapiens | Human | PF01392 PF07679 PF13927 PF07714 | 7.9 | Kd | BindingDB |
| P36507 | MAP2K2 | Homo sapiens | Human | PF00069 | 7.9 | Kd | BindingDB |
| P08922 | ROS1 | Homo sapiens | Human | PF00041 PF07714 | 7.8 | Kd | BindingDB |
| Q14289 | PTK2B | Homo sapiens | Human | PF21477 PF00373 PF18038 PF03623 PF07714 | 7.8 | Kd | BindingDB |
| P08631 | HCK | Homo sapiens | Human | PF07714 PF00017 PF00018 | 7.8 | Kd | BindingDB |
| O43283 | MAP3K13 | Homo sapiens | Human | PF07714 | 7.8 | Kd | BindingDB |
| Q9H3Y6 | SRMS | Homo sapiens | Human | PF07714 PF00017 | 7.7 | Kd | BindingDB |
| P12931 | SRC | Homo sapiens | Human | PF07714 PF00017 PF00018 | 7.7 | Kd | BindingDB |
| O43353 | RIPK2 | Homo sapiens | Human | PF00619 PF07714 | 7.7 | Kd | BindingDB |
| Q13470 | TNK1 | Homo sapiens | Human | PF07714 PF22931 | 7.7 | Kd | BindingDB |
| Q12852 | MAP3K12 | Homo sapiens | Human | PF07714 | 7.7 | Kd | BindingDB |
| P42684 | ABL2 | Homo sapiens | Human | PF08919 PF07714 PF00017 PF00018 | 7.6 | Kd | BindingDB |
| Q8TBX8 | PIP4K2C | Homo sapiens | Human | PF01504 | 7.5 | Kd | BindingDB |
| O94921 | CDK14 | Homo sapiens | Human | PF00069 | 7.5 | Kd | BindingDB |
| Q96Q40 | CDK15 | Homo sapiens | Human | PF00069 | 7.5 | Kd | BindingDB |
| P16591 | FER | Homo sapiens | Human | PF00611 PF07714 PF00017 | 7.4 | Kd | BindingDB |
| P00519 | ABL1 | Homo sapiens | Human | PF08919 PF07714 PF00017 PF00018 | 7.4 | Kd | BindingDB |
| P09769 | FGR | Homo sapiens | Human | PF07714 PF00017 PF00018 | 7.4 | Kd | BindingDB |
| Q96GD4 | AURKB | Homo sapiens | Human | PF00069 | 7.4 | Kd | BindingDB |
| Q9H422 | HIPK3 | Homo sapiens | Human | PF00069 | 7.4 | Kd | BindingDB |
| Q92918 | MAP4K1 | Homo sapiens | Human | PF00780 PF00069 | 7.4 | Kd | BindingDB |
| Q9NYL2 | MAP3K20 | Homo sapiens | Human | PF07714 PF07647 | 7.3 | Kd | BindingDB |
| P07947 | YES1 | Homo sapiens | Human | PF07714 PF00017 PF00018 | 7.3 | Kd | BindingDB |
| P14616 | INSRR | Homo sapiens | Human | PF00041 PF00757 PF07714 PF01030 | 7.3 | Kd | BindingDB |
| O15264 | MAPK13 | Homo sapiens | Human | PF00069 | 7.3 | Kd | BindingDB |
| O96017 | CHEK2 | Homo sapiens | Human | PF00498 PF00069 | 7.2 | Kd | BindingDB |
| Q08881 | ITK | Homo sapiens | Human | PF00779 PF00169 PF07714 PF00017 PF00018 | 7.2 | Kd | BindingDB |
| Q9UM73 | ALK | Homo sapiens | Human | PF12810 PF00629 PF07714 | 7.2 | Kd | BindingDB |
| Q8TD08 | MAPK15 | Homo sapiens | Human | PF00069 | 7.1 | Kd | BindingDB |
| Q9BUB5 | MKNK1 | Homo sapiens | Human | PF00069 | 7.1 | Kd | BindingDB |
| Q06187 | BTK | Homo sapiens | Human | PF00779 PF00169 PF07714 PF00017 PF00018 | 7.1 | Kd | BindingDB |
| P54753 | EPHB3 | Homo sapiens | Human | PF14575 PF25599 PF01404 PF07699 PF00041 PF07714 PF00536 | 7.1 | Kd | BindingDB |
| P06241 | FYN | Homo sapiens | Human | PF07714 PF00017 PF00018 | 7.1 | Kd | BindingDB |
| Q9BWU1 | CDK19 | Homo sapiens | Human | PF00069 | 7.1 | Kd | BindingDB |
| Q9BYT3 | STK33 | Homo sapiens | Human | PF00069 | 7.0 | Kd | BindingDB |
| P07332 | FES | Homo sapiens | Human | PF00611 PF07714 PF00017 | 7.0 | Kd | BindingDB |
| P29376 | LTK | Homo sapiens | Human | PF12810 PF07714 | 7.0 | Kd | BindingDB |
| Q8IVH8 | MAP4K3 | Homo sapiens | Human | PF00780 PF00069 | 7.0 | Kd | BindingDB |
| P41240 | CSK | Homo sapiens | Human | PF07714 PF00017 PF00018 | 6.9 | Kd | BindingDB |
| P49336 | CDK8 | Homo sapiens | Human | PF00069 | 6.9 | Kd | BindingDB |
| Q59H18 | TNNI3K | Homo sapiens | Human | PF12796 PF07714 | 6.9 | Kd | BindingDB |
| P57059 | SIK1 | Homo sapiens | Human | PF00069 PF23312 | 6.8 | Kd | BindingDB |
| Q00537 | CDK17 | Homo sapiens | Human | PF00069 | 6.8 | Kd | BindingDB |
| Q9UBE8 | NLK | Homo sapiens | Human | PF00069 | 6.8 | Kd | BindingDB |
| Q05397 | PTK2 | Homo sapiens | Human | PF21477 PF00373 PF18038 PF03623 PF07714 | 6.7 | Kd | BindingDB |
| Q6DT37 | CDC42BPG | Homo sapiens | Human | PF00130 PF00780 PF08826 PF25346 PF00069 PF00433 | 6.7 | Kd | BindingDB |
| Q9NRP7 | STK36 | Homo sapiens | Human | PF13646 PF00069 | 6.7 | Kd | BindingDB |
| O95819 | MAP4K4 | Homo sapiens | Human | PF00780 PF00069 | 6.7 | Kd | BindingDB |
| P00533 | EGFR | Homo sapiens | Human | PF00757 PF14843 PF07714 PF01030 PF21314 | 6.7 | Kd | BindingDB |
| P51813 | BMX | Homo sapiens | Human | PF00779 PF00169 PF07714 PF00017 | 6.7 | Kd | BindingDB |
| Q07912 | TNK2 | Homo sapiens | Human | PF09027 PF11555 PF07714 PF22931 PF14604 | 6.7 | Kd | BindingDB |
| P06213 | INSR | Homo sapiens | Human | PF00757 PF17870 PF07714 PF01030 | 6.7 | Kd | BindingDB |
| Q14004 | CDK13 | Homo sapiens | Human | PF00069 | 6.7 | Kd | BindingDB |
| Q9UKE5 | TNIK | Homo sapiens | Human | PF00780 PF00069 | 6.7 | Kd | BindingDB |
| Q9H2X6 | HIPK2 | Homo sapiens | Human | PF00069 | 6.7 | Kd | BindingDB |
| Q8TDR2 | STK35 | Homo sapiens | Human | PF00069 | 6.6 | Kd | BindingDB |
| Q92772 | CDKL2 | Homo sapiens | Human | PF00069 | 6.6 | Kd | BindingDB |
| Q07002 | CDK18 | Homo sapiens | Human | PF00069 | 6.6 | Kd | BindingDB |
| Q15569 | TESK1 | Homo sapiens | Human | PF07714 | 6.6 | Kd | BindingDB |
| P43405 | SYK | Homo sapiens | Human | PF07714 PF00017 | 6.5 | Kd | BindingDB |
| Q14680 | MELK | Homo sapiens | Human | PF02149 PF00069 PF21594 | 6.5 | Kd | BindingDB |
| P42680 | TEC | Homo sapiens | Human | PF00779 PF00169 PF07714 PF00017 PF00018 | 6.5 | Kd | BindingDB |
| Q16539 | MAPK14 | Homo sapiens | Human | PF00069 | 6.5 | Kd | BindingDB |
| Q9Y5S2 | CDC42BPB | Homo sapiens | Human | PF00130 PF00780 PF08826 PF15796 PF25346 PF00069 | 6.5 | Kd | BindingDB |
| Q16584 | MAP3K11 | Homo sapiens | Human | PF07714 PF14604 | 6.5 | Kd | BindingDB |
| Q9Y616 | IRAK3 | Homo sapiens | Human | PF00531 PF00069 | 6.4 | Kd | BindingDB |
| P53778 | MAPK12 | Homo sapiens | Human | PF00069 | 6.4 | Kd | BindingDB |
| Q86Z02 | HIPK1 | Homo sapiens | Human | PF00069 | 6.4 | Kd | BindingDB |
| P08069 | IGF1R | Homo sapiens | Human | PF00757 PF07714 PF01030 | 6.4 | Kd | BindingDB |
| P33981 | TTK | Homo sapiens | Human | PF00069 | 6.4 | Kd | BindingDB |
| O14965 | AURKA | Homo sapiens | Human | PF00069 | 6.4 | Kd | BindingDB |
| Q6PHR2 | ULK3 | Homo sapiens | Human | PF04212 PF00069 | 6.3 | Kd | BindingDB |
| Q8TD19 | NEK9 | Homo sapiens | Human | PF00069 PF25390 | 6.3 | Kd | BindingDB |
| Q9UQ88 | CDK11A | Homo sapiens | Human | PF00069 | 6.3 | Kd | BindingDB |
| Q6XUX3 | DSTYK | Homo sapiens | Human | PF00069 | 6.3 | Kd | BindingDB |
| P42681 | TXK | Homo sapiens | Human | PF07714 PF00017 PF00018 | 6.3 | Kd | BindingDB |
| Q02779 | MAP3K10 | Homo sapiens | Human | PF07714 PF14604 | 6.3 | Kd | BindingDB |
| O43318 | MAP3K7 | Homo sapiens | Human | PF07714 | 6.3 | Kd | BindingDB |
| P49759 | CLK1 | Homo sapiens | Human | PF00069 | 6.3 | Kd | BindingDB |
| Q8N5S9 | CAMKK1 | Homo sapiens | Human | PF00069 | 6.3 | Kd | BindingDB |
| P04626 | ERBB2 | Homo sapiens | Human | PF00757 PF14843 PF07714 PF01030 PF21314 | 6.2 | Kd | BindingDB |
| Q15303 | ERBB4 | Homo sapiens | Human | PF00757 PF14843 PF07714 PF01030 PF21314 | 6.2 | Kd | BindingDB |
| P21127 | CDK11B | Homo sapiens | Human | PF00069 | 6.2 | Kd | BindingDB |
| Q9H0K1 | SIK2 | Homo sapiens | Human | PF00069 PF23312 | 6.2 | Kd | BindingDB |
| Q5VT25 | CDC42BPA | Homo sapiens | Human | PF00130 PF00780 PF08826 PF15796 PF25346 PF00069 PF00433 | 6.2 | Kd | BindingDB |
| P45984 | MAPK9 | Homo sapiens | Human | PF00069 | 6.2 | Kd | BindingDB |
| P53667 | LIMK1 | Homo sapiens | Human | PF00412 PF00595 PF07714 | 6.2 | Kd | BindingDB |
| P11362 | FGFR1 | Homo sapiens | Human | PF07679 PF00047 PF07714 | 6.2 | Kd | BindingDB |
| Q8WXR4 | MYO3B | Homo sapiens | Human | PF00612 PF00063 PF00069 | 6.2 | Kd | BindingDB |
| Q13131 | PRKAA1 | Homo sapiens | Human | PF16579 PF21147 PF00069 | 6.1 | Kd | BindingDB |
| Q15759 | MAPK11 | Homo sapiens | Human | PF00069 | 6.1 | Kd | BindingDB |
| P21802 | FGFR2 | Homo sapiens | Human | PF07679 PF13927 PF07714 | 6.1 | Kd | BindingDB |
| Q9UHD2 | TBK1 | Homo sapiens | Human | PF00069 PF18394 PF18396 | 6.1 | Kd | BindingDB |
| Q13546 | RIPK1 | Homo sapiens | Human | PF00531 PF07714 | 6.1 | Kd | BindingDB |
| Q9HAZ1 | CLK4 | Homo sapiens | Human | PF00069 | 6.1 | Kd | BindingDB |
| P57078 | RIPK4 | Homo sapiens | Human | PF12796 PF13637 PF00069 | 6.0 | Kd | BindingDB |
| Q00536 | CDK16 | Homo sapiens | Human | PF00069 | 6.0 | Kd | BindingDB |
| P22607 | FGFR3 | Homo sapiens | Human | PF21165 PF07679 PF13927 PF07714 | 6.0 | Kd | BindingDB |
| Q9BQI3 | EIF2AK1 | Homo sapiens | Human | PF22949 PF00069 | 6.0 | Kd | BindingDB |
| P80192 | MAP3K9 | Homo sapiens | Human | PF07714 PF14604 | 6.0 | Kd | BindingDB |
| P62343 | CDPK1 | Plasmodium falciparum (isolate K1 / Thailand) | Pathogen | PF13499 PF00069 | 6.6 | Kd | BindingDB |