Molecule Details
InChIKeySDTHQOXRWZXTJF-UHFFFAOYSA-N
Compound Name4-(2-methoxyphenyl)-N-(3-methylsulfonylphenyl)pyrimidin-2-amine
Canonical SMILESCOc1ccccc1-c1ccnc(Nc2cccc(S(C)(=O)=O)c2)n1
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)16
Pfam Stratification Cross-Family
Avg pChEMBL6.33
SourceChEMBL
2D Structure
2D structure
Activity Profile
Target Activities (16)
Target Gene Organism Category Pfam pChEMBL Type Source
P50750 CDK9 Homo sapiens Human PF00069 7.5 Ki ChEMBL
Q04771 ACVR1 Homo sapiens Human PF01064 PF07714 PF08515 6.7 Ki ChEMBL
P49840 GSK3A Homo sapiens Human PF00069 6.5 Ki ChEMBL
O14965 AURKA Homo sapiens Human PF00069 6.4 Ki ChEMBL
P49841 GSK3B Homo sapiens Human PF00069 6.4 Ki ChEMBL
P00519 ABL1 Homo sapiens Human PF08919 PF07714 PF00017 PF00018 6.3 Ki ChEMBL
Q00535 CDK5 Homo sapiens Human PF00069 6.3 Ki ChEMBL
Q06418 TYRO3 Homo sapiens Human PF00041 PF07679 PF07714 6.3 Ki ChEMBL
Q9HAZ1 CLK4 Homo sapiens Human PF00069 6.3 Ki ChEMBL
Q5S007 LRRK2 Homo sapiens Human PF23745 PF23744 PF23748 PF16095 PF25497 PF13855 PF00069 PF08477 6.2 Ki ChEMBL
O95819 MAP4K4 Homo sapiens Human PF00780 PF00069 6.1 Ki ChEMBL
P45983 MAPK8 Homo sapiens Human PF00069 6.1 Ki ChEMBL
Q96GD4 AURKB Homo sapiens Human PF00069 6.1 Ki ChEMBL
Q9Y463 DYRK1B Homo sapiens Human PF00069 6.1 Ki ChEMBL
P35968 KDR Homo sapiens Human PF07679 PF00047 PF13895 PF22971 PF07714 PF21339 PF17988 PF22854 6.0 Ki ChEMBL
Q9UQM7 CAMK2A Homo sapiens Human PF08332 PF00069 6.0 Ki ChEMBL