Molecule Details
InChIKeySCLLZBIBSFTLIN-IFMUVJFISA-N
Compound NameMrtx-1133
Canonical SMILESC#Cc1c(F)ccc2cc(O)cc(-c3ncc4c(N5CC6CCC(C5)N6)nc(OC[C@@]56CCCN5C[C@H](F)C6)nc4c3F)c12
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)3
Pfam Stratification Cross-Family
Avg pChEMBL8.89
SourceChEMBL;BindingDB
2D Structure
2D structure
Activity Profile
Target Activities (3)
Target Gene Organism Category Pfam pChEMBL Type Source
P01116 KRAS Homo sapiens Human PF00071 9.4 IC50 ChEMBL;BindingDB
P27361 MAPK3 Homo sapiens Human PF00069 8.6 IC50 ChEMBL
P28482 MAPK1 Homo sapiens Human PF00069 8.6 IC50 ChEMBL