Molecule Details
InChIKeySBWCIJOOABLPME-UHFFFAOYSA-N
Compound Name[4-[4-[4-Amino-7-(oxolan-3-yl)pyrrolo[2,3-d]pyrimidin-5-yl]phenoxy]phenyl]methanol
Canonical SMILESNc1ncnc2c1c(-c1ccc(Oc3ccc(CO)cc3)cc1)cn2C1CCOC1
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)13
Pfam Stratification Cross-Family
Avg pChEMBL7.12
SourceChEMBL
2D Structure
2D structure
Activity Profile
Target Activities (13)
Target Gene Organism Category Pfam pChEMBL Type Source
P06241 FYN Homo sapiens Human PF07714 PF00017 PF00018 8.9 Ki ChEMBL
P06239 LCK Homo sapiens Human PF07714 PF00017 PF00018 8.6 Ki ChEMBL
Q02750 MAP2K1 Homo sapiens Human PF00069 8.3 Ki ChEMBL
P36507 MAP2K2 Homo sapiens Human PF00069 8.2 Ki ChEMBL
P07949 RET Homo sapiens Human PF00028 PF07714 PF17756 PF17812 PF17813 PF22540 7.1 Ki ChEMBL
Q06187 BTK Homo sapiens Human PF00779 PF00169 PF07714 PF00017 PF00018 7.1 Ki ChEMBL
P49336 CDK8 Homo sapiens Human PF00069 6.6 Ki ChEMBL
Q07912 TNK2 Homo sapiens Human PF09027 PF11555 PF07714 PF22931 PF14604 6.5 Ki ChEMBL
P09619 PDGFRB Homo sapiens Human PF00047 PF13927 PF25305 PF07714 6.4 Ki ChEMBL
P16234 PDGFRA Homo sapiens Human PF07679 PF25305 PF07714 6.4 Ki ChEMBL
P35968 KDR Homo sapiens Human PF07679 PF00047 PF13895 PF22971 PF07714 PF21339 PF17988 PF22854 6.4 Ki ChEMBL
P36888 FLT3 Homo sapiens Human PF00047 PF07714 6.0 Ki ChEMBL
Q96GD4 AURKB Homo sapiens Human PF00069 6.0 Ki ChEMBL