Molecule Details
| InChIKey | SAPNXPWPAUFAJU-UHFFFAOYSA-N |
|---|---|
| Compound Name | Lofepramine |
| Canonical SMILES | CN(CCCN1c2ccccc2CCc2ccccc21)CC(=O)c1ccc(Cl)cc1 |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 10 |
| Pfam Stratification | Cross-Family |
| Avg pChEMBL | 6.92 |
| Source | BindingDB |
2D Structure
Activity Profile
DrugBank Annotations
| DrugBank ID | DB13411 |
|---|---|
| Drug Name | Lofepramine |
| CAS Number | 23047-25-8 |
| Groups | experimental |
| ATC Codes | N06AA07 |
| Description | nan |
Categories: Agents that produce hypertension Agents that reduce seizure threshold Antidepressive Agents Antidepressive Agents, Tricyclic Central Nervous System Agents Central Nervous System Depressants Dibenzazepines Heterocyclic Compounds, Fused-Ring Nervous System Neurotoxic agents Non-Selective Monoamine Reuptake Inhibitors Psychoanaleptics Psychotropic Drugs Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome
Cross-references: BindingDB: 82437 ChEBI: 47782 CHEMBL87708 ChemSpider: 3810 RxCUI: 6465 Wikipedia: Lofepramine ZINC: ZINC000001542929
Target Activities (10)
| Target | Gene | Organism | Category | Pfam | pChEMBL | Type | Source |
|---|---|---|---|---|---|---|---|
| P23975 | SLC6A2 | Homo sapiens | Human | PF00209 | 8.3 | Ki | BindingDB |
| P11229 | CHRM1 | Homo sapiens | Human | PF00001 | 7.2 | Ki | BindingDB |
| P31645 | SLC6A4 | Homo sapiens | Human | PF03491 PF00209 | 7.2 | Ki | BindingDB |
| P35348 | ADRA1A | Homo sapiens | Human | PF00001 | 7.0 | Ki | BindingDB |
| P20309 | CHRM3 | Homo sapiens | Human | PF00001 | 6.9 | Ki | BindingDB |
| P08172 | CHRM2 | Homo sapiens | Human | PF00001 | 6.8 | Ki | BindingDB |
| P28335 | HTR2C | Homo sapiens | Human | PF00001 | 6.7 | Ki | BindingDB |
| P08173 | CHRM4 | Homo sapiens | Human | PF00001 | 6.5 | Ki | BindingDB |
| P35367 | HRH1 | Homo sapiens | Human | PF00001 | 6.4 | Ki | BindingDB |
| P08912 | CHRM5 | Homo sapiens | Human | PF00001 | 6.3 | Ki | BindingDB |